Nallagonda Rajender, Reddy Reddy Rajasekhar, Ghorai Prasanta
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Indore By-pass Road, Bhopal-462066 (India).
Chemistry. 2015 Oct 12;21(42):14732-6. doi: 10.1002/chem.201502781. Epub 2015 Aug 28.
A new palladium-catalyzed intramolecular oxidative cycloisomerization of readily available starting materials, 2-cinnamyl-1,3-dicarbonyls, has been demonstrated for the creation of structurally diverse 2-benzyl furans. The cycloisomerization occurs by a regioselective 5-exo-trig pathway. The reaction shows a broad substrate scope with good to excellent yields. Furthermore, a one-pot procedure has been executed by using readily available cinnamyl alcohols and 1,3-diketones.
已证明，一种新型钯催化的分子内氧化环异构化反应可用于构建结构多样的2-苄基呋喃，该反应以易于获得的起始原料2-肉桂基-1,3-二羰基化合物为底物。环异构化反应通过区域选择性的5-外向-叁角途径进行。该反应底物范围广泛，产率良好至优异。此外，还利用易于获得的肉桂醇和1,3-二酮实现了一锅法合成。
