Su Miao-Shang, Zhang Hai-Lin, Cai Xiao-Hong, Lin Ying, Liu Pei-Ning, Zhang Yuan-Bo, Hu Wen-Zhen, Li Chang-Chong, Xiao Yan-Feng
Department of Pediatrics, The 2nd Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shanxi Province, People's Republic of China.
Department of Pediatrics, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China.
Eur J Pediatr. 2016 Feb;175(2):211-20. doi: 10.1007/s00431-015-2613-6. Epub 2015 Aug 28.
This study investigated the association between obesity and obstructive sleep apnea (OSA) in preschool and school-age children. Parents of obese and randomly chosen normal weight children completed a questionnaire on sleep-related symptoms, demography, family, and medical history. All subjects were invited to undergo polysomnography (PSG). OSA cases were defined as obstructive apnea hypopnea index (OAHI) ≥1. A total of 5930 children were studied with 9.5% obese (11.9% boys/6.1% girls), 205/2680 preschool and 360/3250 school children. There were 1030 children (535 obese/495 normal weight) who underwent PSG. OSA was higher in obese children and obese school children had higher OAHI, arousal index, and shorter total sleep time. However, there was no positive correlation between OSA and body mass index (BMI). The main risk factors for OSA in preschool children were adenotonsillar hypertrophy and recurrent respiratory tract infection. The main cause for OSA in school children was a history of parental snoring and obesity. Mallampati scores and sleep-related symptoms were found to be associated with OSA in both preschool and school children.
We demonstrated differential risk factors for OSA in obese children, which suggest that a different mechanism may be involved in OSA development in preschool and school-age children.
Various risk factors have been reported in obese children with OSA owing to the different age and different study design. Obese children have a higher prevalence and severity of obstructive sleep apnea (OSA). OSA risk factors in obese children are affected by different ages and study designs.
A differential prevalence and risk factors for obese preschool and school-age children with OSA has been demonstrated.
本研究调查了学龄前和学龄儿童肥胖与阻塞性睡眠呼吸暂停(OSA)之间的关联。肥胖儿童和随机选取的正常体重儿童的家长完成了一份关于睡眠相关症状、人口统计学、家庭和病史的问卷。所有受试者均被邀请接受多导睡眠图(PSG)检查。OSA病例定义为阻塞性呼吸暂停低通气指数(OAHI)≥1。共对5930名儿童进行了研究,其中9.5%为肥胖儿童(男孩占11.9%/女孩占6.1%),205/2680名学龄前儿童和360/3250名学龄儿童。共有1030名儿童(535名肥胖儿童/495名正常体重儿童)接受了PSG检查。肥胖儿童的OSA发生率更高,肥胖学龄儿童的OAHI、觉醒指数更高,总睡眠时间更短。然而,OSA与体重指数(BMI)之间没有正相关。学龄前儿童OSA的主要危险因素是腺样体扁桃体肥大和反复呼吸道感染。学龄儿童OSA的主要原因是父母打鼾史和肥胖。发现Mallampati评分和睡眠相关症状在学龄前和学龄儿童中均与OSA有关。
我们证明了肥胖儿童OSA的不同危险因素,这表明学龄前和学龄儿童OSA的发生可能涉及不同的机制。
由于年龄不同和研究设计不同,肥胖OSA儿童已报告了各种危险因素。肥胖儿童阻塞性睡眠呼吸暂停(OSA)的患病率和严重程度更高。肥胖儿童的OSA危险因素受不同年龄和研究设计的影响。
已证明肥胖学龄前和学龄儿童OSA的患病率和危险因素存在差异。