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呼吸道过敏与食物过敏之间的关系及预防措施评估

Relationship between respiratory and food allergy and evaluation of preventive measures.

作者信息

Vega F, Panizo C, Dordal M T, González M L, Velázquez E, Valero A, Sánchez M C, Rondón C, Montoro J, Matheu V, Lluch-Bernal M, González R, Fernández-Parra B, Del Cuvillo A, Dávila I, Colás C, Campo P, Antón E, Navarro A M

机构信息

Department of Allergy, Hospital de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain.

Department of Allergy, Hospital Nuestra Señora del Prado, Toledo, Spain.

出版信息

Allergol Immunopathol (Madr). 2016 May-Jun;44(3):263-75. doi: 10.1016/j.aller.2015.05.008. Epub 2015 Aug 25.

Abstract

Food allergy and respiratory allergy are two frequently associated diseases and with an increasing prevalence. Several reports show the presence of respiratory symptoms in patients with food allergy, while certain foods may be related to the development or exacerbation of allergic rhinitis and asthma. The present update focuses on this relationship, revealing a pathogenic and clinical association between food and respiratory allergy. This association is even more intense when the food hypersensitivity is persistent or starts in the early years of life. Food allergy usually precedes respiratory allergy and may be a risk factor for allergic rhinitis and asthma, becoming a relevant clinical marker for severe atopic asthma. Furthermore, the presence of co-existing asthma may enhance life-threatening symptoms occurring during a food allergic reaction. Recommendations for dietary restrictions during pregnancy and breastfeeding to prevent the development of respiratory allergy are controversial and not supported by consistent scientific data. Current recommendations from medical societies propose exclusive breastfeeding during the first four months of life, with the introduction of solid food in the fourth to the seventh month period of life. A delayed introduction of solid food after this period may increase the risk of developing subsequent allergic conditions. Further studies are encouraged to avoid unjustified recommendations involving useless dietary restrictions.

摘要

食物过敏和呼吸道过敏是两种常伴发且患病率不断上升的疾病。多项报告显示,食物过敏患者存在呼吸道症状,而某些食物可能与过敏性鼻炎和哮喘的发生或加重有关。本次更新聚焦于这种关系,揭示了食物过敏与呼吸道过敏之间的致病及临床关联。当食物超敏反应持续存在或在生命早期开始时,这种关联更为强烈。食物过敏通常先于呼吸道过敏出现,可能是过敏性鼻炎和哮喘的危险因素,成为重度特应性哮喘的一个重要临床指标。此外,同时存在哮喘可能会加重食物过敏反应期间出现的危及生命的症状。关于孕期和哺乳期饮食限制以预防呼吸道过敏发生的建议存在争议,且缺乏一致的科学数据支持。医学协会目前的建议是在生命的前四个月进行纯母乳喂养,在第四个月至第七个月期间引入固体食物。在此之后延迟引入固体食物可能会增加后续发生过敏疾病的风险。鼓励开展进一步研究,以避免提出涉及无必要饮食限制的不合理建议。

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