Michał Wojasiński, Ewa Duszyńska, Tomasz Ciach
BioMedical Engineering Laboratory, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, 00-645 Warszawa, Poland.
Colloid Polym Sci. 2015;293(5):1561-1568. doi: 10.1007/s00396-015-3557-0. Epub 2015 Mar 15.
Hydroxyapatite Ca(PO)(OH) nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant-lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.
在生物相容性天然表面活性剂卵磷脂存在的情况下，于60℃通过湿化学沉淀法成功合成了羟基磷灰石Ca(PO)(OH)纳米颗粒。采用X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和扫描电子显微镜（SEM）研究了用卵磷脂合成的羟基磷灰石纳米颗粒（nHAp-PC）的组成和形态。通过NanoSight系统中的纳米颗粒跟踪分析测量纳米颗粒的尺寸分布。我们详细讨论了反应体系中卵磷脂浓度对nHAp-PC形态以及纳米颗粒尺寸分布和悬浮性的影响。产物呈现出羟基磷灰石的晶体结构和化学成分，并带有明显的卵磷脂痕迹。表面活性剂用量的差异导致颗粒形态及其平均尺寸发生变化。
