X连锁视网膜色素变性患者周边眼底的自发荧光
Radial fundus autofluorescence in the periphery in patients with X-linked retinitis pigmentosa.
作者信息
Ogino Ken, Oishi Maho, Oishi Akio, Morooka Satoshi, Sugahara Masako, Gotoh Norimoto, Kurimoto Masafumi, Yoshimura Nagahisa
机构信息
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan ; Center for Genomic Medicine, Kyoto University, Kyoto, Japan.
出版信息
Clin Ophthalmol. 2015 Aug 17;9:1467-74. doi: 10.2147/OPTH.S89371. eCollection 2015.
PURPOSE
To describe the peripheral autofluorescence images and clinical features of patients with retinal dystrophy who showed radial fundus autofluorescence (FAF) at the posterior pole.
METHODS
The authors retrospectively reviewed pooled wide-field FAF images of 711 patients with retinal dystrophy and 56 family members.
RESULTS
Eleven eyes of seven women exhibited radial FAF at the posterior pole. Wide-field FAF showed extension of the radial pattern to the periphery in all eyes except one. One woman showed radial hyper-FAF only in the periphery, not at the posterior pole. These eight individuals were X-linked retinitis pigmentosa patients or carriers. The tapetal-like reflex was not observed in their color fundus photographs. The peripheral visual field showed wedge-shaped restriction in some individuals.
CONCLUSION
Wide-field FAF imaging can depict radial FAF not only at the posterior pole but also in the periphery in X-linked retinitis pigmentosa carriers. The authors therefore agree with previous reports that radial FAF may be a hallmark of X-linked retinitis pigmentosa.
目的
描述后极部出现放射状眼底自发荧光（FAF）的视网膜营养不良患者的周边自发荧光图像及临床特征。
方法
作者回顾性分析了711例视网膜营养不良患者及56名家庭成员的广角FAF图像。
结果
7名女性的11只眼后极部出现放射状FAF。除1只眼外，广角FAF显示所有眼睛的放射状模式均延伸至周边。1名女性仅周边出现放射状高自发荧光，后极部未出现。这8名个体为X连锁视网膜色素变性患者或携带者。其彩色眼底照片中未观察到毯样反光。部分个体周边视野呈楔形缺损。
结论
广角FAF成像不仅可显示X连锁视网膜色素变性携带者后极部的放射状FAF，还可显示周边的放射状FAF。因此，作者认同既往报道，即放射状FAF可能是X连锁视网膜色素变性的一个标志。
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