Inui Emiko, Oishi Akio, Oishi Maho, Ogino Ken, Makiyama Yukiko, Gotoh Norimoto, Kurimoto Masafumi, Yoshimura Nagahisa
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54, Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Graefes Arch Clin Exp Ophthalmol. 2014 Jul;252(7):1065-9. doi: 10.1007/s00417-014-2570-1. Epub 2014 Jan 18.
To investigate the relationship between impairment of cone/rod photoreceptors and changes in optical coherence tomography (OCT) findings.
We retrospectively reviewed the clinical records of 35 patients with cone-rod dystrophy (CRD) and 35 visual acuity-matched patients with retinitis pigmentosa (RP). The presence or absence of the external limiting membrane (ELM), inner segment ellipsoid (ISe), interdigitation zone (IZ), and foveal cavitation (hyporeflective space in the outer retina) were determined using OCT image evaluation.
There were no statistical differences in the number of CRD and RP patients with an intact ELM and ISe. None of the CRD patients had an intact IZ, but 20 % of RP patients did (P = 0.011). In addition, foveal cavitation tended to be observed more frequently in CRD patients than (25.7 %) in RP patients (5.7 %) despite the difference not being significant after the correction of multiple comparison.
Eyes with CRD and RP had significant differences in foveal morphology, even when visual acuity was matched. This result supports the notion that absence of an IZ and the presence of foveal cavitation is related to cone-dominant photoreceptor impairment.
研究视锥/视杆光感受器损伤与光学相干断层扫描（OCT）结果变化之间的关系。
我们回顾性分析了35例锥杆营养不良（CRD）患者和35例视力匹配的视网膜色素变性（RP）患者的临床记录。使用OCT图像评估来确定是否存在外限制膜（ELM）、内节椭圆体（ISe）、指状交叉带（IZ）和黄斑空洞（视网膜外层低反射区）。
ELM和ISe完整的CRD患者和RP患者数量无统计学差异。所有CRD患者的IZ均不完整，但20%的RP患者的IZ完整（P = 0.011）。此外，尽管在多重比较校正后差异不显著，但CRD患者中黄斑空洞的发生率（25.7%）往往高于RP患者（5.7%）。
即使视力匹配，CRD和RP患者的黄斑形态仍存在显著差异。这一结果支持了IZ缺失和黄斑空洞的存在与视锥细胞占主导的光感受器损伤有关的观点。
