Liu Xue-Jun, Liu Wen-Lian, Yang Fang-Mei, Yang Xiao-Qing, Lu Xiao-Fei
Department of Obstetrics, Linyi Hospital Affiliated to Shandong University, Linyi City, People's Republic of China.
Department of Pathology, Qianfoshan Hospital Affiliated to Shandong University, Jinan City, People's Republic of China.
Onco Targets Ther. 2015 Aug 13;8:2101-9. doi: 10.2147/OTT.S85660. eCollection 2015.
To evaluate the expression and clinical significance of hepatoma-derived growth factor (HDGF) in epithelial ovarian cancer (EOC).
Recent studies have demonstrated that HDGF overexpression correlates to the progression and poor prognosis in several kinds of cancers. However, the clinical significance and prognostic value of HDGF in EOC have not been investigated.
Expression of HDGF was visualized by immunohistology and then the cohort was divided into higher- and lower-expression groups. The correlation between HDGF and clinicopathologic factors was analyzed by χ (2) test. The prognostic value of HDGF was assessed by univariate analysis with Kaplan-Meier method, and by multivariate analysis with Cox-regression model. With experiments in vitro, HDGF expression in ovarian cancer cell lines was detected by immunoblotting.
Higher HDGF expression rate was 52.76% in EOC. HDGF expression was significantly associated with lymphatic metastasis (P=0.006). Higher HDGF expression was closely correlated to poorer 5-year overall survival rate with univariate analysis (P=0.003), and was identified as an independent prognostic factor with multivariate analysis (P=0.007). With experiments in vitro, HDGF was proved to exist in all ovarian cancer cell lines with different expression levels.
HDGF expression correlates to unfavorable prognosis and can be considered as an independent prognostic factor, indicating that HDGF may be a promising potential molecular drug target.
评估肝癌衍生生长因子（HDGF）在上皮性卵巢癌（EOC）中的表达及其临床意义。
最近的研究表明，HDGF的过表达与几种癌症的进展和不良预后相关。然而，HDGF在EOC中的临床意义和预后价值尚未得到研究。
通过免疫组织化学观察HDGF的表达，然后将队列分为高表达组和低表达组。采用χ²检验分析HDGF与临床病理因素之间的相关性。采用Kaplan-Meier法进行单因素分析，采用Cox回归模型进行多因素分析，评估HDGF的预后价值。通过体外实验，采用免疫印迹法检测卵巢癌细胞系中HDGF的表达。
EOC中HDGF的高表达率为52.76%。HDGF表达与淋巴结转移显著相关（P = 0.006）。单因素分析显示，HDGF高表达与较差的5年总生存率密切相关（P = 0.003），多因素分析确定其为独立预后因素（P = 0.007）。体外实验证明，HDGF存在于所有表达水平不同的卵巢癌细胞系中。
HDGF表达与不良预后相关，可被视为独立的预后因素，表明HDGF可能是一个有前景的潜在分子药物靶点。
