[确定灰红链霉菌产生的蒽环酮类化合物的结构]
[Establishing the structure of anthracyclinones produced by Streptomyces griseoruber].
作者信息
Bakina E V, Iartseva I V, Povarov L S, Aleksandrova L G, Tulemisova K A, Mamonova L P, Preobrazhenskaia M N
出版信息
Bioorg Khim. 1989 Oct;15(10):1423-30.
Streptomyces grisoruber strain 1618-306 produces three types of anthracycline antibiotics, derivatives of epsilon-pyrromycinone (methyl (7S, 9R, 10R)-9-ethyl-5,7,8,9,10,12-hexahydro-1,4,6,7,9-pentahydroxy-5,12-di oxo-10- naphthacenecarboxylate), epsilon-1-hydroxyauramycinone and epsilon-1-hydroxysulfurmycinone, differing in C-9 substituent in D ring of anthracyclines (Et, Met or CH2COCH3, respectively). Besides 7-O-glycosides of these aglycones, complex of antibiotics contains corresponding 7-deoxy- and 7,8,9,10-bisanhydroanthracyclinones.
灰红链霉菌菌株1618 - 306产生三种类型的蒽环类抗生素，即ε-吡咯霉素酮（甲基(7S, 9R, 10R)-9-乙基-5,7,8,9,10,12-六氢-1,4,6,7,9-五羟基-5,12-二氧代-10-萘并萘甲酸酯）的衍生物、ε-1-羟基金霉素酮和ε-1-羟基硫霉素酮，它们在蒽环类化合物D环的C-9取代基上有所不同（分别为Et、Met或CH2COCH3）。除了这些苷元的7-O-糖苷外，抗生素复合物还包含相应的7-脱氧和7,8,9,10-双脱水蒽环酮。
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