Implicating Interneurons: Optogenetic Studies Suggest That Interneurons Are Guilty of Contributing to Epileptiform Activity.
作者信息
Maguire Jamie L
出版信息
Epilepsy Curr. 2015 Jul-Aug;15(4):213-6. doi: 10.5698/1535-7511-15.4.213.
Abstract
摘要
相似文献
1
Implicating Interneurons: Optogenetic Studies Suggest That Interneurons Are Guilty of Contributing to Epileptiform Activity.牵连中间神经元：光遗传学研究表明中间神经元促成癫痫样活动。
Epilepsy Curr. 2015 Jul-Aug;15(4):213-6. doi: 10.5698/1535-7511-15.4.213.
2
Interneuron subtype specific activation of mGluR1/5 during epileptiform activity in hippocampus.海马区癫痫样活动中 mGluR1/5 型中间神经元亚群的特异性激活。
Epilepsia. 2010 Aug;51(8):1607-18. doi: 10.1111/j.1528-1167.2010.02689.x. Epub 2010 Aug 4.
3
The antiepileptic and ictogenic effects of optogenetic neurostimulation of PV-expressing interneurons.对表达小白蛋白的中间神经元进行光遗传学神经刺激的抗癫痫和致痫作用。
J Neurophysiol. 2016 Oct 1;116(4):1694-1704. doi: 10.1152/jn.00744.2015. Epub 2016 Jul 13.
4
Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation.短暂激活 GABA 能中间神经元通过抑制后反弹兴奋引发发作事件的转变。
Neurobiol Dis. 2018 Jan;109(Pt A):102-116. doi: 10.1016/j.nbd.2017.10.007. Epub 2017 Oct 10.
5
Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis.对特定神经元群进行光遗传学低频刺激可减少癫痫发作的发生。
J Neurosci. 2017 Mar 15;37(11):2999-3008. doi: 10.1523/JNEUROSCI.2244-16.2017. Epub 2017 Feb 16.
6
Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis.抑制性还是兴奋性？光遗传学探讨 GABA 能中间神经元在癫痫发生中的功能作用。
J Biomed Sci. 2017 Dec 5;24(1):93. doi: 10.1186/s12929-017-0399-8.
7
Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex.选择性激活表达小白蛋白或生长抑素的中间神经元会在小鼠内侧内嗅皮层引发癫痫样发作活动。
J Neurophysiol. 2015 Mar 1;113(5):1616-30. doi: 10.1152/jn.00841.2014. Epub 2014 Dec 10.
8
Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity.癫痫样活动期间锥体细胞和中间神经元中依赖碳酸氢盐的去极化电位。
Eur J Neurosci. 2003 Sep;18(5):1337-42. doi: 10.1046/j.1460-9568.2003.02843.x.
9
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.光遗传学抑制小鼠化学诱导的超同步爆发。
Neurobiol Dis. 2014 May;65:133-41. doi: 10.1016/j.nbd.2014.01.015. Epub 2014 Jan 31.
10
When a Good Cop Turns Bad: The Pro-Ictal Action of Parvalbumin Expressing Interneurons During Seizures.当好警察变坏时：癫痫发作期间表达小白蛋白的中间神经元的发作期作用。
Epilepsy Curr. 2019 Jul-Aug;19(4):256-257. doi: 10.1177/1535759719853548. Epub 2019 Jun 4.
引用本文的文献
1
Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer's Disease.神经紊乱疾病中的颗粒蛋白前体细胞衍生蛋白（Parvalbumin）中间神经元功能障碍：聚焦于癫痫和阿尔茨海默病。
Int J Mol Sci. 2024 May 19;25(10):5549. doi: 10.3390/ijms25105549.
2
An Electric Light Orchestra in the Brain: Optogenetics for Controlling Seizures via Modulation of Astrocyte Activity.大脑中的“电光乐队”：通过调节星形胶质细胞活动来控制癫痫发作的光遗传学
Epilepsy Curr. 2023 Mar 29;23(3):188-190. doi: 10.1177/15357597231160600. eCollection 2023 May-Jun.
3
Seizing Sequencing Data to Consider Cell and Circuit Complexity.利用测序数据考量细胞和回路复杂性。
Epilepsy Curr. 2019 Mar-Apr;19(2):124-125. doi: 10.1177/1535759719835658.
4
Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research.特异性、多功能性与持续发展：光遗传学在癫痫研究中的力量
Front Cell Neurosci. 2018 Jun 14;12:151. doi: 10.3389/fncel.2018.00151. eCollection 2018.
5
Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex.光遗传学激活表达 VGLUT2 的兴奋性神经元可阻断小鼠内嗅皮层的癫痫样发作活动。
Sci Rep. 2017 Feb 23;7:43230. doi: 10.1038/srep43230.
6
Compromised GABAergic inhibition contributes to tumor-associated epilepsy.γ-氨基丁酸能抑制作用受损会导致肿瘤相关性癫痫。
Epilepsy Res. 2016 Oct;126:185-96. doi: 10.1016/j.eplepsyres.2016.07.010. Epub 2016 Jul 27.
本文引用的文献
1
Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation.通过使用低频光刺激经中间神经元介导的同步化来减少癫痫发作
Exp Neurol. 2015 Jul;269:120-32. doi: 10.1016/j.expneurol.2015.04.001. Epub 2015 Apr 8.
2
Optogenetics and epilepsy: past, present and future.光遗传学与癫痫：过去、现在和未来。
Epilepsy Curr. 2015 Jan-Feb;15(1):34-8. doi: 10.5698/1535-7597-15.1.34.
3
Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy.小脑定向光遗传学干预可抑制颞叶癫痫小鼠模型中的海马自发性癫痫发作。
eNeuro. 2014 Dec;1(1). doi: 10.1523/ENEURO.0005-14.2014.
4
Interneuron activity leads to initiation of low-voltage fast-onset seizures.中间神经元活动会引发低电压快速发作性癫痫。
Ann Neurol. 2015 Mar;77(3):541-6. doi: 10.1002/ana.24342. Epub 2015 Feb 14.
5
Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex.选择性激活表达小白蛋白或生长抑素的中间神经元会在小鼠内侧内嗅皮层引发癫痫样发作活动。
J Neurophysiol. 2015 Mar 1;113(5):1616-30. doi: 10.1152/jn.00841.2014. Epub 2014 Dec 10.
6
Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges.表达小白蛋白的中间神经元的兴奋作用通过同步后放电维持海马癫痫样活动。
J Neurosci. 2014 Nov 12;34(46):15208-22. doi: 10.1523/JNEUROSCI.1747-14.2014.
7
Long-term seizure suppression and optogenetic analyses of synaptic connectivity in epileptic mice with hippocampal grafts of GABAergic interneurons.长期癫痫发作抑制及对移植了GABA能中间神经元的癫痫小鼠突触连接性的光遗传学分析
J Neurosci. 2014 Oct 1;34(40):13492-504. doi: 10.1523/JNEUROSCI.0005-14.2014.
8
Global optogenetic activation of inhibitory interneurons during epileptiform activity.在癫痫样活动期间对抑制性中间神经元进行全局光遗传学激活。
J Neurosci. 2014 Feb 26;34(9):3364-77. doi: 10.1523/JNEUROSCI.2734-13.2014.
9
A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons.癫痫模型中的 GABA 能回路重组：来自光遗传标记和生长抑素中间神经元刺激的证据。
J Neurosci. 2013 Sep 4;33(36):14392-405. doi: 10.1523/JNEUROSCI.2045-13.2013.
10
On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy.按需光遗传学控制颞叶癫痫的自发性癫痫发作。
Nat Commun. 2013;4:1376. doi: 10.1038/ncomms2376.
Zotero 插件