Assistant Investigator, Gladstone Institute of Neurological Disease, UCSF, San Francisco, CA ; Consulting Assistant Professor of Neurology, Stanford School of Medicine, Stanford, CA ; Assistant Professor of Neurology and Neuroscience, University of California, San Francisco, CA.
Professor of Neurology, Stanford School of Medicine, Stanford, CA.
Epilepsy Curr. 2015 Jan-Feb;15(1):34-8. doi: 10.5698/1535-7597-15.1.34.
The holy grail of epilepsy research is to understand the mechanisms underlying seizures so that patients with epilepsy can receive effective treatment or be cured, ideally with no significant side effects. Recent advances in neuroscience give such hope. Optogenetics is a modern neuroscience research tool that allows precise spatiotemporal control of defined cells and circuits and, thus, dissection of critical players and targeting them for responsive treatments. Here we review the state of the art of these approaches and their applications and implications in epilepsy research.
癫痫研究的圣杯是理解癫痫发作的机制,以便癫痫患者能够接受有效治疗或治愈,理想情况下没有明显的副作用。神经科学的最新进展给人带来了这样的希望。光遗传学是一种现代神经科学研究工具,可以精确地控制特定细胞和回路的时空活动,从而对关键参与者进行剖析,并针对这些参与者进行有针对性的治疗。本文综述了这些方法的最新进展及其在癫痫研究中的应用和意义。