Almatroodi Saleh A, McDonald Christine F, Pouniotis Dodie S
Cancer & Tissue Repair Laboratory, RMIT University, Bundoora, VIC 3083, Australia ; Applied Medical Sciences College, Qassim University, Buraidah 51452, Saudi Arabia.
Institute for Breathing & Sleep, Austin Health, Heidelberg, VIC 3084, Australia.
Lung Cancer Int. 2014;2014:721087. doi: 10.1155/2014/721087. Epub 2014 May 8.
The role of alveolar macrophages in lung cancer is multifaceted and conflicting. Alveolar macrophage secretion of proinflammatory cytokines has been found to enhance antitumour functions, cytostasis (inhibition of tumour growth), and cytotoxicity (macrophage-mediated killing). In contrast, protumour functions of alveolar macrophages in lung cancer have also been indicated. Inhibition of antitumour function via secretion of the anti-inflammatory cytokine IL-10 as well as reduced secretion of proinflammatory cytokines and reduction of mannose receptor expression on alveolar macrophages may contribute to lung cancer progression and metastasis. Alveolar macrophages have also been found to contribute to angiogenesis and tumour growth via the secretion of IL-8 and VEGF. This paper reviews the evidence for a dual role of alveolar macrophages in lung cancer progression.
肺泡巨噬细胞在肺癌中的作用是多方面且相互矛盾的。已发现肺泡巨噬细胞分泌促炎细胞因子可增强抗肿瘤功能、细胞生长抑制（抑制肿瘤生长）和细胞毒性（巨噬细胞介导的杀伤）。相比之下，也有研究表明肺泡巨噬细胞在肺癌中具有促肿瘤作用。通过分泌抗炎细胞因子白细胞介素-10抑制抗肿瘤功能，以及肺泡巨噬细胞上促炎细胞因子分泌减少和甘露糖受体表达降低，可能会促进肺癌的进展和转移。还发现肺泡巨噬细胞通过分泌白细胞介素-8和血管内皮生长因子促进血管生成和肿瘤生长。本文综述了肺泡巨噬细胞在肺癌进展中双重作用的证据。
