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神经影像学中的偶然发现:伦理与法医学考量

Incidental Findings in Neuroimaging: Ethical and Medicolegal Considerations.

作者信息

Leung Lawrence

机构信息

Centre of Neurosciences Study, Queen's University, 18 Stuart Street, Kingston, ON, Canada K7L 3N6 ; Centre of Studies in Primary Care, Queen's University, 220 Bagot Street, Kingston, ON, Canada K7L 5E9 ; Department of Family Medicine, Queen's University, 220 Bagot Street, Kingston, ON, Canada K7L 5E9.

出版信息

Neurosci J. 2013;2013:439145. doi: 10.1155/2013/439145. Epub 2012 Nov 20.

Abstract

With the rapid advances in neurosciences in the last three decades, there has been an exponential increase in the use of neuroimaging both in basic sciences and clinical research involving human subjects. During routine neuroimaging, incidental findings that are not part of the protocol or scope of research agenda can occur and they often pose a challenge as to how they should be handled to abide by the medicolegal principles of research ethics. This paper reviews the issue from various ethical (do no harm, general duty to rescue, and mutual benefits and owing) and medicolegal perspectives (legal liability, fiduciary duties, Law of Tort, and Law of Contract) with a suggested protocol of approach.

摘要

在过去三十年里,随着神经科学的迅速发展,神经成像技术在基础科学和涉及人类受试者的临床研究中的应用呈指数级增长。在常规神经成像过程中,可能会出现不属于研究方案或研究议程范围的偶然发现,而如何处理这些发现以遵守研究伦理的法医学原则往往是一个挑战。本文从各种伦理(不伤害、一般救助义务、互利与亏欠)和法医学角度(法律责任、信托义务、侵权法和合同法)对该问题进行了综述,并提出了一个建议的处理方案。

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