Onaolapo Olakunle James, Onaolapo Adejoke Yetunde
Department of Pharmacology, Ladoke Akintola University of Technology, PMB 5000, Ogbomoso, Nigeria.
Department of Human Anatomy, Ladoke Akintola University of Technology, PMB 5000, Ogbomoso, Nigeria.
Neurosci J. 2013;2013:948241. doi: 10.1155/2013/948241. Epub 2012 Dec 6.
This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehavioral tests were carried out on days 1 and 21 after administration. Open field assessment on day 1 after administration revealed significant increase in grooming at 2.5 and 5 mg/kg, while horizontal and vertical locomotion showed no significant changes. Day 1 also showed no significant changes in Y-maze alternation. On day 21, horizontal locomotion, rearing, and grooming were increased significantly at 2.5 and 5 mg/kg doses after administration; also, spatial memory was significantly enhanced at 2.5 mg/kg. In conclusion, the study demonstrates the ability of oral bromocriptine to affect neurobehavior in normal mice. It also suggests that there is a cumulative effect of oral bromocriptine on the behaviors studied with more changes being seen after subchronic administration rather than after a single oral dose.
本研究旨在通过旷场实验和Y迷宫实验评估亚慢性口服甲磺酸溴隐亭对健康雄性小鼠神经行为的影响。将60只成年瑞士白化小鼠分为三组。对照组给予生理盐水，而实验组分别给予2.5和5毫克/千克/天的甲磺酸溴隐亭，持续21天。给药后第1天和第21天进行神经行为测试。给药后第1天的旷场实验评估显示，2.5和5毫克/千克剂量组的理毛行为显著增加，而水平和垂直运动无显著变化。第1天的Y迷宫交替实验也无显著变化。在第21天，给药后2.5和5毫克/千克剂量组的水平运动、竖毛和理毛行为显著增加；此外，2.5毫克/千克剂量组的空间记忆显著增强。总之，该研究证明了口服溴隐亭对正常小鼠神经行为的影响能力。这也表明，口服溴隐亭对所研究行为具有累积效应，亚慢性给药后比单次口服剂量后观察到更多变化。
