Jahan K, Tabrizian M
Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC H3A 2B2, Canada.
Biomater Sci. 2016 Jan;4(1):25-39. doi: 10.1039/c5bm00163c.
For the past century, various biomaterials have been used in the treatment of bone defects and fractures. Their role as potential substitutes for human bone grafts increases as donors become scarce. Metals, ceramics and polymers are all materials that confer different advantages to bone scaffold development. For instance, biocompatibility is a highly desirable property for which naturally-derived polymers are renowned. While generally applied separately, the use of biomaterials, in particular natural polymers, is likely to change, as biomaterial research moves towards mixing different types of materials in order to maximize their individual strengths. This review focuses on osteoconductive biocomposite scaffolds which are constructed around natural polymers and their performance at the in vitro/in vivo stages and in clinical trials.
在过去的一个世纪里，各种生物材料已被用于治疗骨缺损和骨折。随着骨移植供体变得稀缺，它们作为人类骨移植潜在替代品的作用日益凸显。金属、陶瓷和聚合物都是为骨支架开发带来不同优势的材料。例如，生物相容性是天然衍生聚合物所闻名的非常理想的特性。虽然通常单独应用，但随着生物材料研究朝着混合不同类型材料以最大化其各自优势的方向发展，生物材料尤其是天然聚合物的使用可能会发生变化。本综述重点关注围绕天然聚合物构建的骨传导性生物复合支架及其在体外/体内阶段和临床试验中的性能。
