Department of Biomedical Engineering, McGill University, Montreal, Quebec H3A 2B4, Canada.
Shriner's Hospital for Children, Montreal, Quebec H4A 0A9 Canada.
ACS Appl Bio Mater. 2023 Jul 17;6(7):2515-2545. doi: 10.1021/acsabm.3c00108. Epub 2023 Jun 13.
An increasing number of publications over the past ten years have focused on the development of chitosan-based cross-linked scaffolds to regenerate bone tissue. The design of biomaterials for bone tissue engineering applications relies heavily on the ideals set forth by a polytherapy approach called the "Diamond Concept". This methodology takes into consideration the mechanical environment, scaffold properties, osteogenic and angiogenic potential of cells, and benefits of osteoinductive mediator encapsulation. The following review presents a comprehensive summarization of recent trends in chitosan-based cross-linked scaffold development within the scope of the Diamond Concept, particularly for nonload-bearing bone repair. A standardized methodology for material characterization, along with assessment of and potential for bone regeneration, is presented based on approaches in the literature, and future directions of the field are discussed.
在过去的十年中，越来越多的出版物专注于开发基于壳聚糖的交联支架来再生骨组织。用于骨组织工程应用的生物材料的设计在很大程度上依赖于一种多疗法方法，即“钻石概念”所提出的理想。该方法考虑了机械环境、支架特性、细胞的成骨和成血管潜能以及骨诱导介质包封的益处。以下综述全面总结了钻石概念范围内基于壳聚糖的交联支架发展的最新趋势，特别是对于非承重骨修复。根据文献中的方法，提出了一种材料特性的标准化方法，以及对骨再生潜力的评估，并讨论了该领域的未来方向。
