Lyck Hansen Maria, Dahl Thomsen Marie, Rasmussen Lars Melholt, Lindholt Jes S
1 Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Denmark.
Vasa. 2015 Sep;44(5):349-53. doi: 10.1024/0301-1526/a000453.
Measure of arterial stiffness could be affected by the presence of abdominal aortic aneurysm (AAA) and especially an intraluminal thrombus (ILT). We, therefore, sought to study this possible connection by measuring pulse wave velocity (PWV) and pulse wave analysis (PWA) including augmentation index adjusted to heart rate 75 (Aix75) in patients with AAA ± ILT.
PWV and PWA were measured in male patients with AAA from an ongoing Danish AAA screening trial. Information on blood pressure, medications, BMI and smoking status was obtained at inclusion.
In total, 157 patients were included. Mean age was 73 years. Mean AAA size was 42.2 mm. Fifty-six of the patients had an intraluminal thrombus, and patients with AAA and ILT had a significantly higher Aix75 than patients with AAA but without ILT (Mean = 28.3 ± 1.4 SEM vs. 24.9 ± 0.81, p=0.027), a difference that was also significant when adjusting for AAA size, blood pressure and age. There was no difference in PWV between the groups.
Haemodynamic properties of the aorta are affected by the presence of ILT in patients with AAA that is not explained by aortic size. Alternatively, these findings could be explained by associations between ILT and properties of the left ventricle.
腹主动脉瘤（AAA）尤其是腔内血栓（ILT）的存在可能会影响动脉僵硬度的测量。因此，我们试图通过测量AAA ± ILT患者的脉搏波速度（PWV）和脉搏波分析（PWA）（包括根据心率75调整的增强指数（Aix75））来研究这种可能的联系。
从正在进行的丹麦AAA筛查试验中选取男性AAA患者测量PWV和PWA。纳入时获取血压、用药情况、体重指数和吸烟状况等信息。
共纳入157例患者。平均年龄73岁。AAA平均大小为42.2 mm。56例患者有腔内血栓，有AAA和ILT的患者的Aix75显著高于有AAA但无ILT的患者（均值 = 28.3 ± 1.4 SEM对24.9 ± 0.81，p = 0.027），在调整AAA大小、血压和年龄后，这种差异仍显著。两组间PWV无差异。
AAA患者中ILT的存在会影响主动脉的血流动力学特性，这无法用主动脉大小来解释。或者，这些发现可以用ILT与左心室特性之间的关联来解释。
