Lee S D, Ahn G H, Chi J G, Ham E K
Department of Pathology, Seoul National University Hospital, Korea.
J Korean Med Sci. 1989 Sep;4(3):155-8. doi: 10.3346/jkms.1989.4.3.155.
Clear-cell chondrosarcoma, a recently specified entity, is a low-grade malignant tumor and has characteristic clinical, roentgenographic and pathologic findings which separate it from conventional chondrosarcoma and other benign tumors. Therefore, correct diagnosis is important from the viewpoint of both prognosis and therapeutic approach. We report a case of typical recurrent clear-cell chordirosarcoma. Typical round cells with clear cytoplasm, large nuclei, and small nucleoli were wellnoted. The clear cytoplasm was faintly positive in PAS staining. Electronmicroscopic study showed that these cells were of chondroid origin, showing indented nuclei, large dilated endoplasmic reticulum cisternae, bundles of actin-like filaments and a few glycogen particles.
透明细胞软骨肉瘤是一种最近明确的实体肿瘤，是一种低度恶性肿瘤，具有特征性的临床、影像学和病理学表现，使其与传统软骨肉瘤及其他良性肿瘤相区别。因此，从预后和治疗方法的角度来看，正确诊断很重要。我们报告一例典型复发性透明细胞软骨肉瘤病例。可见典型的圆形细胞，胞质透明、核大、核仁小。透明胞质在PAS染色中呈弱阳性。电镜研究显示这些细胞起源于软骨样细胞，表现为核凹陷、内质网池大扩张、肌动蛋白样细丝束和少量糖原颗粒。
