Kuroda Naoto, Sogoh Toshiharu, Ohara Masahiko, Hirouchi Takashi, Mizuno Keiko, Hayashi Yoshihiro, Lee Gang-Hong
Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780-8562, Japan.
Med Mol Morphol. 2009 Sep;42(3):185-8. doi: 10.1007/s00795-007-0359-6. Epub 2009 Sep 26.
Clear cell chondrosarcoma (CCC) is a rare neoplasm. We report here a case of CCC. A 67-year-old Japanese man presented with right arthralgia for 1 year, and histological examination of the subsequent surgical resection of the right femoral bone showed the finding of CCC. Ultrastructurally, most organelles were observed in the perinuclear area. Clear neoplastic cells contained many glycogen particles in the area of the cytoplasm lacking organelles, although glycogen particles overall seemed to be evenly distributed in the cytoplasm. Some mitochondria, Golgi complex, actin-like filaments, and rough endoplasmic reticulum were also demonstrated in the cytoplasm of clear cells. Well-developed microvilli were also seen on the surface of neoplastic cells. These structures in neoplastic cells corresponded notably to structures of normal chondrocytes. Finally, our ultrastructural findings support further evidence that clear cells in CCC may show chondrocyte differentiation and a lack of an organelles area as well as abundant glycogen particles, may contribute to the clear cell morphology in CCC.
透明细胞软骨肉瘤（CCC）是一种罕见的肿瘤。我们在此报告一例CCC病例。一名67岁的日本男性因右关节痛就诊1年，随后对右侧股骨进行手术切除的组织学检查显示为CCC。超微结构上，大多数细胞器见于核周区域。透明的肿瘤细胞在缺乏细胞器的细胞质区域含有许多糖原颗粒，尽管糖原颗粒总体上似乎均匀分布于细胞质中。透明细胞的细胞质中还可见一些线粒体、高尔基体、肌动蛋白样细丝和粗面内质网。肿瘤细胞表面也可见发育良好的微绒毛。肿瘤细胞中的这些结构与正常软骨细胞的结构明显对应。最后，我们的超微结构研究结果进一步证明，CCC中的透明细胞可能显示软骨细胞分化，缺乏细胞器区域以及丰富的糖原颗粒，可能导致CCC中的透明细胞形态。
