微小RNA-10a在非小细胞肺癌中上调，可能通过靶向磷酸酶和张力蛋白同源物（PTEN）来促进癌症发展。

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN.

作者信息

Yu Tao, Liu Lei, Li Jing, Yan Mingxia, Lin Hechun, Liu Ying, Chu Dandan, Tu Hong, Gu Aiqin, Yao Ming

机构信息

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

Oncotarget. 2015 Oct 6;6(30):30239-50. doi: 10.18632/oncotarget.4972.

MicroRNAs (miRNAs) are involved in human cancer including non-small cell lung cancer (NSCLC). In this study, we compared miRNA expression microarray of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells. We found that miRNA-10a was up-regulated in NSCLC compared with corresponding normal tissues. High expression of miR-10a was associated with tumor node metastasis and lymph node metastasis. Furthermore, overexpression of miR-10a promoted NSCLC cell proliferation, migration and invasion in vitro. We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN.