El-Khoury Joseph, Sahakian Nayiri
a Consultant Adult and Addiction Psychiatrist, Department of Psychiatry , American University of Beirut Medical Center , Beirut , Lebanon.
b PGY-4 Psychiatry, Department of Psychiatry and Clinical Psychology , St. George Hospital University Medical Center , Beirut , Lebanon.
J Psychoactive Drugs. 2015 Sep-Oct;47(4):286-92. doi: 10.1080/02791072.2015.1073815. Epub 2015 Aug 28.
The association of substance abuse and psychotic disorders is of interest to clinicians, academics, and lawmakers. Commonly abused substances, such as cannabis, cocaine, amphetamines, and alcohol, have all been associated with substance-induced psychosis. Hallucinogens can induce desired psychedelic effects and undesirable psychomimetic reactions. These are usually transient and resolve once the duration of action is over. Sometimes, these effects persist, causing distress and requiring intervention. This article focuses on the hallucinogenic substance Salvia divinorum, the use of which has been observed, particularly among youth worldwide. We present background information based on a review of the literature and on our own clinical encounters, as highlighted by two original case reports. We hypothesize that consumption of Salvia divinorum could be associated with the development of psychotic disorders. We propose that clinicians routinely inquire about the use of Salvia in patients with substance use disorders or psychotic illnesses. More research is required to assess any relationship between Salvia divinorum and psychosis. Additionally, we advocate increased public and medical awareness of this substance and other emerging drugs of abuse.
药物滥用与精神障碍之间的关联引起了临床医生、学者和立法者的关注。常见的滥用药物，如大麻、可卡因、安非他命和酒精，都与药物所致精神病有关。致幻剂可诱发预期的迷幻效果和不良的拟精神病反应。这些反应通常是短暂的，一旦作用期结束就会消退。有时，这些效应会持续存在，造成痛苦并需要干预。本文重点关注致幻物质鼠尾草，其使用情况已被观察到，尤其是在全球范围内的年轻人中。我们根据文献综述和我们自己的临床经验提供背景信息，两篇原始病例报告突出了这些内容。我们假设食用鼠尾草可能与精神障碍的发展有关。我们建议临床医生常规询问患有物质使用障碍或精神疾病的患者是否使用过鼠尾草。需要更多研究来评估鼠尾草与精神病之间的任何关系。此外，我们主张提高公众和医学界对这种物质及其他新兴滥用药物的认识。
