Prisinzano Thomas E
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, S327 PHAR, MNPC, 115 S. Grand Ave., Iowa City, IW 52242, USA.
Life Sci. 2005 Dec 22;78(5):527-31. doi: 10.1016/j.lfs.2005.09.008. Epub 2005 Oct 6.
At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has resulted in various on-line botanical companies advertising and selling S. divinorum as a legal alternative to other regulated plant hallucinogens. It is predictable that its misuse will increase rapidly. The active ingredient in S. divinorum is the neoclerodane diterpene, salvinorin A (1a), which has been shown to be a kappa agonist both in vitro and in vivo. This review will cover the current state of research into the psychopharmacology of S. divinorum.
目前，墨西哥薄荷鼠尾草是一种不受管制的致幻剂。这导致各种在线植物公司将鼠尾草作为其他受管制植物致幻剂的合法替代品进行宣传和销售。可以预见，其滥用情况将迅速增加。鼠尾草中的活性成分是新克罗烷二萜类化合物——鼠尾草酸（1a），已证明其在体外和体内均为κ激动剂。本综述将涵盖鼠尾草精神药理学的当前研究状况。
