Jalilvand Somayeh, Marashi Sayed Mahdi, Tafakhori Abbas, Shoja Zabihollah
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2015 Sep;18(9):604-5.
Rotaviruses (RVs), a member of Reoviridae family, are a major cause of severe diarrhea in children < 5 years of age worldwide, infecting mainly the gastrointestinal tract although recent findings have shown extraintestinal spread of RV infections. The RV is known to cause systemic infection in children with acute gastroenteritis (AGE). The systemic RV infection may lead to the virus reaching extraintestinal organs, therefore developing clinical symptoms. RV RNA, antigen, and infectious particles have been found in serum, cerebrospinal fluid (CSF) and extraintestinal tissues in children with AGE. According to previous studies on molecular genotyping of RV, no specific association has been yet found between antigenemia and RV G genotype. However, nucleotide changes and genotype discordance in RVs have been detected in paired stool and serum samples. In children, who show the evidence of antigenemia, RV genome is detectable in extraintestinal organs. Although, clinical significance of the laboratory findings remains to be determined.
轮状病毒（RVs）属于呼肠孤病毒科，是全球5岁以下儿童严重腹泻的主要病因，主要感染胃肠道，不过最近的研究发现RV感染可发生肠外传播。已知RV可导致急性胃肠炎（AGE）患儿发生全身感染。全身性RV感染可能导致病毒到达肠外器官，从而出现临床症状。在AGE患儿的血清、脑脊液（CSF）和肠外组织中发现了RV RNA、抗原和感染性颗粒。根据先前关于RV分子基因分型的研究，尚未发现抗原血症与RV G基因型之间存在特定关联。然而，在配对的粪便和血清样本中检测到了RV的核苷酸变化和基因型不一致。在有抗原血症证据的儿童中，RV基因组可在肠外器官中检测到。尽管如此，这些实验室检查结果的临床意义仍有待确定。
