用于检测癌症干细胞中Fe(3+)的罗丹明功能化石墨烯量子点
Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe(3+) in Cancer Stem Cells.
作者信息
Guo Ruihua, Zhou Shixin, Li Yunchao, Li Xiaohong, Fan Louzhen, Voelcker Nicolas H
机构信息
Department of Chemistry, Beijing Normal University , Beijing 100875, P. R. China.
Department of Cell Biology, School of Basic Medicine, Peking University Health Science Center , Beijing 100191, P. R. China.
出版信息
ACS Appl Mater Interfaces. 2015 Nov 4;7(43):23958-66. doi: 10.1021/acsami.5b06523. Epub 2015 Oct 26.
A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe(3+) detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 μM are demonstrated as a Fe(3+) turn-on fluorescent nanosensor in cancer stem cells. Fe(3+) binding to such GQDs (RBD-GQDs-Fe(3+)) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
一种基于罗丹明B衍生物功能化石墨烯量子点（RBD-GQDs）的开启型橙红色荧光纳米传感器已成功合成，用于高灵敏度和高选择性地检测Fe(3+)。通过与石墨烯量子点连接，罗丹明B的水溶性、灵敏度、光稳定性和生物相容性得到了极大提高。RBD-GQDs与其他先前报道的荧光团或石墨烯量子点最显著的区别在于，它们在癌症干细胞中作为Fe(3+)开启型荧光纳米传感器，检测限低至0.02 μM。Fe(3+)与这种具有43%量子产率的橙红色荧光的石墨烯量子点（RBD-GQDs-Fe(3+)）结合，被证明是癌症干细胞成像的生物标志物。
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