SIRT1在苯并[a]芘诱导的肺癌发生过程中的作用
SIRT1 in B[a]P-induced lung tumorigenesis.
作者信息
Lu Jianyi, Zhang Min, Huang Zhiyong, Sun Sufang, Zhang Yongliang, Zhang Lei, Peng Lirong, Ma Ailing, Ji Pan, Dai Jia, Cui Tong, Liu Heping, Gao Jimin
机构信息
Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Department of Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
出版信息
Oncotarget. 2015 Sep 29;6(29):27113-29. doi: 10.18632/oncotarget.4729.
Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane fraction of E-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesis of BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-α/β-catenin axis and is as a potential therapeutic target for lung cancer.
苯并[a]芘（B[a]P）是香烟烟雾中的一种致癌物。我们发现B[a]P可在人支气管上皮BEAS-2B细胞中诱导SIRT1表达。SIRT1在暴露于B[a]P的小鼠肺部以及人类肺癌活检组织中过表达。SIRT1上调肿瘤坏死因子-α（TNF-α）和β-连环蛋白，并下调E-钙黏蛋白的膜组分。此外，SIRT1促进了B[a]P暴露后BEAS-2B细胞在裸鼠体内的侵袭、迁移和肿瘤发生。因此，SIRT1参与了与TNF-α/β-连环蛋白轴激活相关的B[a]P诱导的细胞转化过程，并且是肺癌的一个潜在治疗靶点。
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