长寿的基本机制：以果蝇长寿基因为例的研究

Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.

作者信息

Proshkina Ekaterina N, Shaposhnikov Mikhail V, Sadritdinova Asiya F, Kudryavtseva Anna V, Moskalev Alexey A

机构信息

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

出版信息

Ageing Res Rev. 2015 Nov;24(Pt B):218-31. doi: 10.1016/j.arr.2015.08.005. Epub 2015 Aug 28.

DOI:10.1016/j.arr.2015.08.005

PMID:26318059

Abstract

Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.

摘要

果蝇是衰老和长寿遗传学中最便捷的模式生物之一。与线虫不同，线虫可通过基因敲除和RNA干扰介导的基因敲低来检测新的促衰老基因，而果蝇还提供了通过驱动诱导过表达来寻找新的长寿基因的机会。对其他模型进行的类似研究极为罕见。在本综述中，我们重点关注那些过表达能延长果蝇寿命的基因。大多数与长寿相关的基因调节代谢和抗应激能力，属于IGF-1R、PI3K、PKB、AMPK和TOR代谢调节簇以及FOXO、HDAC、p53应激反应簇。