Pierrefite-Carle Valérie, Santucci-Darmanin Sabine, Breuil Véronique, Camuzard Olivier, Carle Georges F
UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France.
UMR E-4320 TIRO-MATOs CEA/iBEB, Université Nice Sophia Antipolis, Faculté de Médecine Nice, France.
Ageing Res Rev. 2015 Nov;24(Pt B):206-17. doi: 10.1016/j.arr.2015.08.004. Epub 2015 Aug 28.
Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging.
自噬是一种负责清除受损蛋白质和细胞器的主要分解代谢途径，现在被认为是一种抗衰老过程。除了在细胞稳态中的基础作用外，自噬也是一种出于生存目的的应激反应机制。在这里，我们回顾最近的文献，以突出自噬在不同骨细胞类型（即成骨细胞、破骨细胞和骨细胞）中的作用。我们还讨论了自噬调节剂在骨生理学中的作用以及骨合成代谢化合物在自噬中的作用。最后，我们分析了关于骨细胞自噬缺陷小鼠模型的研究，以更全面地了解自噬如何调节骨生理学和病理生理学，特别是在衰老过程中。
