Florencio-Silva Rinaldo, Sasso Gisela Rodrigues da Silva, Simões Manuel de Jesus, Simões Ricardo Santos, Baracat Maria Cândida Pinheiro, Sasso-Cerri Estela, Cerri Paulo Sérgio
PhD, Postdoctoral Student, Department of Morphology and Genetics, Division of Histology and Structural Biology, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.
PhD, Postdoctoral Student, Department of Gynecology, Unifesp, São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2017 Feb;63(2):173-179. doi: 10.1590/1806-9282.63.02.173.
Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
自噬是一种生存途径，在该途径中，无功能的蛋白质和细胞器在溶酶体中被降解，以进行再循环和能量产生。因此，自噬是维持细胞活力的基础，作为一种质量控制过程，可防止不必要的结构积累和氧化应激。越来越多的证据表明，自噬功能障碍与包括神经退行性疾病和癌症在内的多种病理状况有关。此外，最近的研究表明，自噬在维持骨稳态方面发挥着重要作用。例如，体外、动物和人体研究表明，骨细胞中的自噬功能障碍与骨质疏松症等骨疾病的发生有关。本综述旨在讨论该问题，以确认自噬功能障碍与骨质疏松症之间是否存在关联。
