法尼醇是一种存在于香精油中的倍半萜醇，可改善卵清蛋白激发小鼠的血清过敏抗体滴度和脂质分布。
Farnesol, a sesquiterpene alcohol in essential oils, ameliorates serum allergic antibody titres and lipid profiles in ovalbumin-challenged mice.
作者信息
Ku C-M, Lin J-Y
机构信息
Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, ROC.
Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, ROC.
出版信息
Allergol Immunopathol (Madr). 2016 Mar-Apr;44(2):149-59. doi: 10.1016/j.aller.2015.05.009. Epub 2015 Aug 28.
BACKGROUND
Farnesol, a natural sesquiterpene alcohol in essential oils, was found to have potential for alleviating massive inflammation, oxidative stress and lung injury. However, effects of farnesol supplementation on allergic asthma remain unclear.
OBJECTIVES
To clarify the puzzle, this work investigates the effects of farnesol on allergic asthma using an ovalbumin (OVA)-sensitised and challenged mouse model.
METHODS
Farnesol was administered to OVA-sensitised and challenged mice for 5 weeks. Three farnesol doses, namely 5, 25 and 100mg farnesol/kg BW/day, non-sensitised control, dietary control, and positive control (dexamethasone 3mg/kg BW by gavage) were included. Sera and bronchoalveolar lavage fluids from the experimental mice were collected to measure farnesol concentrations, serum lipid profiles, antibody titres, differential cell counts or Th1/Th2 cytokines levels.
RESULTS
The results showed that farnesol supplementation increased serum farnesol concentration dose-dependently, significantly increased (P<0.05) OVA-specific IgG2a/IgE antibody titre ratios, but decreased total IgE levels. Farnesol supplementation markedly reversed the aberrated LDL-c/HDL-c and HDL-c/TC ratios in the sera of asthmatic mice, suggesting that farnesol supplementation might ameliorate serum lipid profiles in the OVA-sensitised and challenged mice.
CONCLUSION
Our results evidenced that farnesol supplementation might improve serum allergic antibody titres and lipid profiles in asthmatic mice.
背景
法尼醇是一种存在于香精油中的天然倍半萜醇，被发现具有缓解大规模炎症、氧化应激和肺损伤的潜力。然而，补充法尼醇对过敏性哮喘的影响仍不清楚。
目的
为了厘清这一谜题，本研究使用卵清蛋白（OVA）致敏和激发的小鼠模型，研究法尼醇对过敏性哮喘的影响。
方法
对OVA致敏和激发的小鼠给予法尼醇，持续5周。设置三个法尼醇剂量组，分别为5、25和100mg法尼醇/千克体重/天，同时设置未致敏对照组、饮食对照组和阳性对照组（通过灌胃给予地塞米松3mg/千克体重）。收集实验小鼠的血清和支气管肺泡灌洗液，以测量法尼醇浓度、血清脂质谱、抗体滴度、细胞分类计数或Th1/Th2细胞因子水平。
结果
结果显示，补充法尼醇可使血清中法尼醇浓度呈剂量依赖性增加，显著提高（P<0.05）OVA特异性IgG2a/IgE抗体滴度比值，但降低总IgE水平。补充法尼醇显著逆转了哮喘小鼠血清中异常的低密度脂蛋白胆固醇/高密度脂蛋白胆固醇和高密度脂蛋白胆固醇/总胆固醇比值，这表明补充法尼醇可能改善OVA致敏和激发小鼠的血清脂质谱。
结论
我们的结果证明，补充法尼醇可能改善哮喘小鼠的血清过敏抗体滴度和脂质谱。
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