Amaral-Machado Lucas, Oliveira Wógenes N, Moreira-Oliveira Susiane S, Pereira Daniel T, Alencar Éverton N, Tsapis Nicolas, Egito Eryvaldo Sócrates T
Graduate Program in Health Sciences, Dispersed System Laboratory (LaSid), Pharmacy Department, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo de Cordeiro-SN-Petrópolis, Natal 59012-570, Brazil.
Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Evid Based Complement Alternat Med. 2020 Feb 13;2020:1021258. doi: 10.1155/2020/1021258. eCollection 2020.
Asthma, a disease classified as a chronic inflammatory disorder induced by airway inflammation, is triggered by a genetic predisposition or antigen sensitization. Drugs currently used as therapies present disadvantages such as high cost and side effects, which compromise the treatment compliance. Alternatively, traditional medicine has reported the use of natural products as alternative or complementary treatment. The aim of this review was to summarize the knowledge reported in the literature about the use of natural products for asthma treatment. The search strategy included scientific studies published between January 2006 and December 2017, using the keywords "asthma," "treatment," and "natural products." The inclusion criteria were as follows: (i) studies that aimed at elucidating the antiasthmatic activity of natural-based compounds or extracts using laboratory experiments ( and/or ; and (ii) studies that suggested the use of natural products in asthma treatment by elucidation of its chemical composition. Studies that (i) did not report experimental data and (ii) manuscripts in languages other than English were excluded. Based on the findings from the literature search, aspects related to asthma physiopathology, epidemiology, and conventional treatment were discussed. Then, several studies reporting the effectiveness of natural products in the asthma treatment were presented, highlighting plants as the main source. Moreover, natural products from animals and microorganisms were also discussed and their high potential in the antiasthmatic therapy was emphasized. This review highlighted the importance of natural products as an alternative and/or complementary treatment source for asthma treatment, since they present reduced side effects and comparable effectiveness as the drugs currently used on treatment protocols.
哮喘是一种被归类为由气道炎症引起的慢性炎症性疾病，由遗传易感性或抗原致敏引发。目前用作治疗的药物存在诸如成本高和副作用等缺点，这会影响治疗依从性。另外，传统医学报道了使用天然产物作为替代或辅助治疗。本综述的目的是总结文献中报道的关于使用天然产物治疗哮喘的知识。检索策略包括2006年1月至2017年12月发表的科学研究，使用关键词“哮喘”“治疗”和“天然产物”。纳入标准如下：（i）旨在通过实验室实验阐明基于天然的化合物或提取物的抗哮喘活性的研究（以及/或者；以及（ii）通过阐明其化学成分表明在哮喘治疗中使用天然产物的研究。排除（i）未报告实验数据的研究以及（ii）非英文语言的手稿。基于文献检索的结果，讨论了与哮喘生理病理学、流行病学和传统治疗相关的方面。然后，介绍了几项报道天然产物在哮喘治疗中有效性的研究，强调植物是主要来源。此外，还讨论了来自动物和微生物的天然产物，并强调了它们在抗哮喘治疗中的巨大潜力。本综述强调了天然产物作为哮喘治疗替代和/或辅助治疗来源的重要性，因为它们副作用较小，且与目前治疗方案中使用的药物有效性相当。
