α-上皮钠通道基因T663A多态性与原发性高血压关系的评估
Evaluation of the relationship between T663A polymorphism in the alpha-epithelial sodium channel gene and essential hypertension.
作者信息
Yang Wenchao, Zhu Zhenmin, Wang Jin, Ye Wei, Ding Yong
机构信息
School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China. E-mail.
出版信息
Saudi Med J. 2015 Sep;36(9):1039-45. doi: 10.15537/smj.2015.9.11822.
OBJECTIVES
To evaluate the relationship between alpha epithelial sodium channel (alpha-ENaC) T663A polymorphism and the risk of essential hypertension.
METHODS
This meta-analysis was conducted between November 2014 and February 2015 in Shanghai Medical Instrumentation College, Shanghai, China. We collected all published available case-control data (N=12) identified through PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI) up to December 2014. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed- or random-effect model.
RESULTS
Although subgroup analysis showed that alpha-ENaC T663A polymorphism was associated with essential hypertension in North American individuals (OR=1.55, 95% CI=1.22-1.98, p=0.0003), our meta-analysis results did not confirm such association overall (OR=1.03, 95% CI=0.92-1.15, p=0.62). The lack of association was further confirmed by the non-superiority test (p less than 0.0001).
CONCLUSION
Alpha-ENaC T663A polymorphism might not be a risk factor for essential hypertension.
目的
评估α上皮钠通道（α-ENaC）T663A多态性与原发性高血压风险之间的关系。
方法
本荟萃分析于2014年11月至2015年2月在中国上海医疗器械高等专科学校进行。我们收集了截至2014年12月通过PubMed、科学网、Scopus和中国知网（CNKI）检索到的所有已发表的可用病例对照数据（N = 12）。使用固定效应模型或随机效应模型计算合并比值比（OR）及其95%置信区间（CI）。
结果
尽管亚组分析显示α-ENaC T663A多态性与北美人群的原发性高血压相关（OR = 1.55，95%CI = 1.22 - 1.98，p = 0.0003），但我们的荟萃分析结果并未总体证实这种关联（OR = 1.03，95%CI = 0.92 - 1.15，p = 0.62）。非劣效性检验进一步证实了这种缺乏关联的情况（p小于0.0001）。
结论
α-ENaC T663A多态性可能不是原发性高血压的危险因素。
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