一项荟萃分析：评估母体白细胞介素-10基因多态性与子痫前期风险的相关性

Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis.

作者信息

Yang Wenchao, Zhu Zhenmin, Wang Jin, Ye Wei, Ding Yong

机构信息

Management Department, Shanghai Medical Instrumentation College, Shanghai, China.

出版信息

J Cell Mol Med. 2014 Dec;18(12):2466-77. doi: 10.1111/jcmm.12434. Epub 2014 Sep 25.

Emerging evidence shows that interleukin (IL)-10 gene polymorphisms can regulate its expression level and thus influence person's susceptibility to preeclampsia. However, various published results were inconsistent. To explore the association between maternal IL-10 gene polymorphisms and preeclampsia, we performed a meta-analysis based upon 11 individual studies here. Our meta-analysis results indicated that IL-10 -819 C/T (C versus T, OR = 1.28, 95% CI = 1.08-1.50, P = 0.003) and -592 C/A (C versus A, OR = 1.28, 95% CI = 1.03-1.59, P = 0.03) polymorphisms were associated with preeclampsia. Although there was no overall association between -1082 A/G polymorphism and preeclampsia (G versus A, OR = 0.93, 95% CI = 0.77-1.13, P = 0.49), such association existed among Asian (G versus A, OR = 1.29, 95% CI = 1.04-1.60, P = 0.02) and South American (G versus A, OR = 0.72, 95% CI = 0.54-0.94, P = 0.02) populations in the subgroup analysis stratified by continents.

新出现的证据表明，白细胞介素（IL）-10基因多态性可调节其表达水平，从而影响个体患先兆子痫的易感性。然而，已发表的各种结果并不一致。为了探讨母体IL-10基因多态性与先兆子痫之间的关联，我们在此基于11项个体研究进行了一项荟萃分析。我们的荟萃分析结果表明，IL-10 -819 C/T（C与T相比，OR = 1.28，95%CI = 1.08 - 1.50，P = 0.003）和-592 C/A（C与A相比，OR = 1.28，95%CI = 1.03 - 1.59，P = 0.03）多态性与先兆子痫相关。虽然-1082 A/G多态性与先兆子痫之间没有总体关联（G与A相比，OR = 0.93，95%CI = 0.77 - 1.13，P = 0.49），但在按大洲分层的亚组分析中，亚洲人群（G与A相比，OR = 1.29，95%CI = 1.04 - 1.60，P = 0.02）和南美人群（G与A相比，OR = 0.72，95%CI = 0.54 - 0.94，P = 0.02）中存在这种关联。