State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; The Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
The Australia-China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, Queensland 4059, Australia; Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
Biomaterials. 2015 Dec;71:35-47. doi: 10.1016/j.biomaterials.2015.08.027. Epub 2015 Aug 18.
A number of coating materials have been developed over past two decades seeking to improve the osseointegration of orthopedic metal implants. Despite the many candidate materials trialed, their low rate of translation into clinical applications suggests there is room for improving the current strategies for their development. We therefore propose that the ideal coating material(s) should possess the following three properties: (i) high bonding strength, (ii) release of functional ions, and (iii) favourable osteoimmunomodulatory effects. To test this proposal, we developed clinoenstatite (CLT, MgSiO3), which as a coating material has high bonding strength, cytocompability and immunomodulatory effects that are favourable for in vivo osteogenesis. The bonding strength of CLT coatings was 50.1 ± 3.2 MPa, more than twice that of hydroxyapatite (HA) coatings, at 23.5 ± 3.5 MPa. CLT coatings released Mg and Si ions, and compared to HA coatings, induced an immunomodulation more conducive for osseointegration, demonstrated by downregurelation of pro-inflammatory cytokines, enhancement of osteogenesis, and inhibition of osteoclastogenesis. In vivo studies demonstrated that CLT coatings improved osseointegration with host bone, as shown by the enhanced biomechanical strength and increased de novo bone formation, when compared with HA coatings. These results support the notion that coating materials with the proposed properties can induce an in vivo environment better suited for osseointegration. These properties could, therefore, be fundamental when developing high-performance coating materials.
在过去的二十年中，已经开发出许多涂层材料，旨在改善骨科金属植入物的骨整合。尽管已经尝试了许多候选材料，但它们在转化为临床应用方面的低转化率表明，仍有改进当前开发策略的空间。因此，我们提出理想的涂层材料应具有以下三个特性：（i）高结合强度，（ii）功能性离子释放，和（iii）有利的骨免疫调节作用。为了验证这一假设，我们开发了斜顽辉石（CLT，MgSiO3）作为涂层材料，具有高结合强度、细胞相容性和有利于体内成骨的免疫调节作用。CLT 涂层的结合强度为 50.1±3.2MPa，是羟基磷灰石（HA）涂层的两倍多，为 23.5±3.5MPa。CLT 涂层释放 Mg 和 Si 离子，与 HA 涂层相比，诱导了更有利于骨整合的免疫调节，表现为促炎细胞因子的下调、成骨增强和破骨细胞生成抑制。体内研究表明，与 HA 涂层相比，CLT 涂层通过增强生物力学强度和增加新骨形成，改善了与宿主骨的骨整合。这些结果支持了这样的观点，即具有所提议特性的涂层材料可以诱导更适合骨整合的体内环境。因此，这些特性可能是开发高性能涂层材料的基础。
