Yang Chen, Zheng Chunquan, Lin Hai, Li Jing, Zhao Keqing
Department of Otolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.
Department of Otolaryngology, Ruijin Hospital, School of medicine, Shanghai Jiao Tong University, 197 Ruijiner Road, Huangpu District, Shanghai, 200025, China.
Inflammation. 2016 Feb;39(1):257-268. doi: 10.1007/s10753-015-0246-6.
The underlying mechanisms of mesenchymal stromal cells (MSCs) on immune modulation to treat allergic diseases remain unclear. Here, we showed that the suppressor of cytokine signaling 3 (SOCS3) is an important immune modulator expressed by MSCs, which is significantly increased by interferon-γ (IFN-γ). In addition, we observed that SOCS3 is a crucial mediator of the anti-proliferative and functional effects of MSCs on T cells and B cells. The immune modulation of MSCs through SOCS3 is mediated by cell-cell contacts. Moreover, SOCS3 could serve as an indicator to predict the potential immune modulatory of MSCs derived from different donors. Furthermore, treatment with anti-SOCS3 Ab significantly decreased ovalbumin-specific antibodies and neutrophil infiltration in ovalbumin-induced allergic rhinitis (AR) mice. Our results suggest that SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulatory of MSCs.
间充质基质细胞（MSCs）用于治疗过敏性疾病的免疫调节潜在机制仍不清楚。在此，我们表明细胞因子信号传导抑制因子3（SOCS3）是MSCs表达的一种重要免疫调节因子，其在干扰素-γ（IFN-γ）作用下显著增加。此外，我们观察到SOCS3是MSCs对T细胞和B细胞的抗增殖及功能影响的关键介质。MSCs通过SOCS3进行的免疫调节由细胞间接触介导。而且，SOCS3可作为预测不同供体来源MSCs潜在免疫调节作用的指标。此外，用抗SOCS3抗体治疗可显著降低卵清蛋白诱导的变应性鼻炎（AR）小鼠中卵清蛋白特异性抗体和中性粒细胞浸润。我们的结果表明，SOCS3作为一种干扰T细胞和B细胞的免疫调节因子，可能充当MSCs免疫调节作用的预测标志物。
