Mohiuddin Muhammad M, Reichart Bruno, Byrne Guerard W, McGregor Christopher G A
Cardiothoracic Surgery Research Program, NHLBI/NIH, USA.
Walter-Brendel-Centre for Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany.
Int J Surg. 2015 Nov;23(Pt B):234-239. doi: 10.1016/j.ijsu.2015.08.038. Epub 2015 Aug 28.
Significant progress in understanding and overcoming cardiac xenograft rejection using a clinically relevant large animal pig-to-baboon model has accelerated in recent years. This advancement is based on improved immune suppression, which attained more effective regulation of B lymphocytes and possibly newer donor genetics. These improvements have enhanced heterotopic cardiac xenograft survival from a few weeks to over 2 years, achieved intrathoracic heterotopic cardiac xenograft survival of 50 days and orthotopic survival of 57 days. This encouraging progress has rekindled interest in xenotransplantation research and refocused efforts on preclinical orthotopic cardiac xenotransplantation.
近年来，使用具有临床相关性的大型动物猪到狒狒模型在理解和克服心脏异种移植排斥方面取得了重大进展。这一进展基于免疫抑制的改善，实现了对B淋巴细胞更有效的调节，以及可能更新的供体遗传学。这些改进将异位心脏异种移植的存活时间从几周延长到了2年多，实现了胸腔内异位心脏异种移植50天的存活时间和原位移植57天的存活时间。这一令人鼓舞的进展重新点燃了人们对异种移植研究的兴趣，并将努力重新聚焦于临床前原位心脏异种移植。
