Al-Rawi Mohammad, Al-Jumaily Ahmed M
Manukau Institute of Technology, Auckland, New Zealand.
Institute of Biomedical Technologies, Auckland University of Technology, Private Bag 92006, City Campus, Auckland, WD301B, New Zealand.
Med Biol Eng Comput. 2016 May;54(5):843-53. doi: 10.1007/s11517-015-1375-7. Epub 2015 Aug 29.
This paper investigates the effect of developing arterial blockage at the abdominal aorta on the blood pressure waves at an externally accessible location suitable for invasive measurements such as the brachial and the femoral arteries. Arterial blockages are created surgically within the abdominal aorta of healthy Wistar rats to create narrowing resemblance conditions. Blood pressure is measured using a catheter inserted into the right femoral artery. Measurements are taken at the baseline healthy condition as well as at four different severities (20, 50, 80 and 100 %) of arterial blockage. In vivo and in vitro measurements of the lumen diameter and wall thickness are taken using magnetic resonance imaging and microscopic techniques, respectively. These data are used to validate a 3D computational fluid dynamics model which is developed to generalize the outcomes of this work and to determine the arterial stress and strain under the blockage conditions. This work indicates that an arterial blockage in excess of 20 % of the lumen diameter significantly influences the pressure wave and reduces the systolic blood pressure at the right femoral artery. High wall shear stresses and low circumferential strains are also generated at the blockage site.
本文研究了腹主动脉出现动脉阻塞对在适合进行侵入性测量的外部可及位置（如肱动脉和股动脉）的血压波的影响。通过手术在健康的Wistar大鼠腹主动脉内制造动脉阻塞，以营造狭窄相似情况。使用插入右股动脉的导管测量血压。在基线健康状况以及动脉阻塞的四种不同严重程度（20%、50%、80%和100%）下进行测量。分别使用磁共振成像和显微镜技术对管腔直径和壁厚进行体内和体外测量。这些数据用于验证一个三维计算流体动力学模型，该模型旨在概括这项工作的结果，并确定阻塞条件下的动脉应力和应变。这项工作表明，管腔直径阻塞超过20%会显著影响压力波，并降低右股动脉的收缩压。阻塞部位还会产生高壁面剪应力和低周向应变。
