Tuerlinckx David, Gueulette Emmanuelle, Loens Katherine, Goossens Herman, Smeesters Pierre Robert
a CHU Dinant-Godinne , Service de Pédiatrie, Université Catholique de Louvain , Yvoir , Belgium.
b Clinique et Maternité St Elisabeth , Service de Pédiatrie , Namur , Belgium.
Acta Clin Belg. 2016 Jun;71(3):138-41. doi: 10.1179/2295333715Y.0000000066. Epub 2016 Jun 6.
As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis.
由于A组链球菌（GAS）脑膜炎在儿童中很少见报道，所以emm型分布数据匮乏。我们报告了比利时8例GAS脑膜炎病例（2008 - 2013年），并将我们菌株的分子特征与之前报道的另外55例及其相应的emm型进行比较。emm1型最为常见（24%），其次是emm6（11%）、emm12（11%）和emm3（6%）。这四种emm型一起占病例的52%，而其余病例则由24种不同的emm型引起。这些与GAS脑膜炎相关的28种emm型属于16个不同的emm簇，这表明没有特定的emm型或emm簇倾向于引起脑膜炎。在患有GAS脑膜炎的儿童中，30价候选疫苗的理论覆盖率将为77.8%（49/63株分离菌）。
