Durá-Travé Teodoro, Gallinas-Victoriano Fidel, Chueca Guindulain María Jesús, Berrade-Zubiri Sara
Departamento de Pediatría, Facultad de Medicina. Universidad de Navarra. Unidad de Endocrinología Pediátrica. Complejo Hospitalario de Navarra. Instituto de Investigación Sanitaria de Navarra (IdisNA), España..
Unidad de Endocrinología Pediátrica. Complejo Hospitalario de Navarra..
Nutr Hosp. 2015 Sep 1;32(3):1061-6. doi: 10.3305/nh.2015.32.3.9316.
to analyze the prevalence of vitamin D deficiency throughout a natural year in a pediatric population with normal nutrition status.
cross sectional clinical and analytical study (calcium, phosphorus, alkaline phosphatase, calcidiol and parathyroid hormone) in 413 caucasian individuals (aged 3.1 to 15.4 years): 227 school children (96 males and 131 females) and 186 adolescents (94 males and 92 females), all of them in a normal nutrition status, during the year 2014. Vitamin D deficiency was defined according to the United States Endocrine Society guidelines.
calcidiol levels were lower during spring (25.96 ± 6.64 ng/ml) and reached its maximum level in summer (35.33 ± 7.51 ng/ml); PTH levels were lower in summer (27.13 ± 7.89 pg/ml) and reached maximum level in autumn (34.73 ± 15.38 pg/ml). Vitamin D deficiency prevalence was 14.3% in summer and 75.3% in spring. PTH levels were compatible with secondary hyperparathyroidism in 8 individuals (1.9%). There was a negative correlation between calcidol and PTH levels (p < 0.01). There was not a correlation between body mass index (BMI) and calcidiol.
the pediatric population in normal nutrition status shows a high prevalence of vitamin D deficiency during the months of autumn and winter and, especially, in spring; the addition of vitamin supplements and/ or an increase in the ingestion of their natural dietary sources should be considered.
分析营养状况正常的儿科人群一自然年内维生素D缺乏症的患病率。
对413名白种人个体（年龄3.1至15.4岁）进行横断面临床及分析研究（检测钙、磷、碱性磷酸酶、骨化二醇和甲状旁腺激素），其中包括227名学龄儿童（96名男性和131名女性）和186名青少年（94名男性和92名女性），所有个体营养状况均正常，研究时间为2014年。根据美国内分泌学会指南定义维生素D缺乏症。
骨化二醇水平在春季较低（25.96±6.64 ng/ml），在夏季达到最高水平（35.33±7.51 ng/ml）；甲状旁腺激素水平在夏季较低（27.13±7.89 pg/ml），在秋季达到最高水平（34.73±15.38 pg/ml）。夏季维生素D缺乏症患病率为14.3%，春季为75.3%。8名个体（1.9%）的甲状旁腺激素水平与继发性甲状旁腺功能亢进相符。骨化二醇和甲状旁腺激素水平呈负相关（p<0.01）。体重指数（BMI）与骨化二醇之间无相关性。
营养状况正常的儿科人群在秋冬季节，尤其是春季，维生素D缺乏症患病率较高；应考虑补充维生素及/或增加天然膳食来源的摄入量。
