T细胞在霍奇金淋巴瘤微环境中的作用。
The role of T cells in the microenvironment of Hodgkin lymphoma.
作者信息
Wein Frederik, Küppers Ralf
机构信息
Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany.
Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany
出版信息
J Leukoc Biol. 2016 Jan;99(1):45-50. doi: 10.1189/jlb.3MR0315-136R. Epub 2015 Aug 28.
Abstract
The cellular microenvironment in HL is dominated by a mixed infiltrate of inflammatory cells with typically only 1 or a few percent of HRS tumor cells. HRS cells orchestrate this infiltrate by the secretion of a multitude of chemokines. T cells are usually the largest population of cells in the HL tissue, encompassing Th cells, T(regs), and CTLs. Th cells and T(regs) presumably provide essential survival signals for the HRS cells, and the T(regs) also play an important role in rescuing HRS cells from an attack by CTLs and NK cells. The interference with this complex interplay of HRS cells with other immune cells in the microenvironment may provide novel strategies for targeted immunotherapies.
摘要
霍奇金淋巴瘤（HL）中的细胞微环境主要由炎症细胞的混合浸润组成，其中典型的霍奇金和里德-斯腾伯格（HRS）肿瘤细胞仅占1%或百分之几。HRS细胞通过分泌多种趋化因子来协调这种浸润。T细胞通常是HL组织中数量最多的细胞群，包括辅助性T细胞（Th细胞）、调节性T细胞（T(regs)）和细胞毒性T淋巴细胞（CTLs）。Th细胞和T(regs)可能为HRS细胞提供重要的生存信号，并且T(regs)在保护HRS细胞免受CTLs和自然杀伤细胞（NK细胞）攻击方面也发挥着重要作用。干扰HRS细胞与微环境中其他免疫细胞之间这种复杂的相互作用可能为靶向免疫疗法提供新的策略。
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