新型8-芳基-7-脱氮鸟嘌呤细胞可渗透荧光探针。
New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.
作者信息
Dhimitruka Ilirian, Eubank Timothy D, Gross Amy C, Khramtsov Valery V
机构信息
Dorothy M. Davis Heart & Lung Research Institute, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United States.
Department of Microbiology, Immunology, and Cell Biology, West Virginia University Health Sciences, Morgantown, VW 26506, United States.
出版信息
Bioorg Med Chem Lett. 2015 Oct 15;25(20):4593-6. doi: 10.1016/j.bmcl.2015.08.054. Epub 2015 Aug 21.
Abstract
A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.
摘要
已经完成了荧光8-芳基-（7-脱氮鸟嘌呤）的一步合成。该探针在各种有机溶液和水溶液中呈现蓝色至绿色的高量子产率荧光、高消光系数，并且通常具有大于100nm的大斯托克斯位移。这些探针具有高度的细胞渗透性，一旦进入细胞内就会呈现稳定的明亮荧光；因此适用于生物传感器的设计。
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