Lucchese Alberta, Gentile Enrica, Capone Giovanni, De Vico Gionata, Serpico Rosario, Landini Gabriel
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Nov;120(5):609-15. doi: 10.1016/j.oooo.2015.06.029. Epub 2015 Jul 6.
The objective of this study was to assess local vascular architecture in atrophic-erosive oral lichen planus (OLP).
We investigated the capillary structure of the oral mucosa in 31 patients with OLP and 32 healthy controls. Capillaries images were captured in vivo through a capillaroscope. We applied fractal analysis to quantify the microvasculature morphometric changes in the oral mucosa of atrophic-erosive OLP patients in terms of their fractal dimension (D).
The oral vascular networks of atrophic-erosive OLP lesions had a significantly higher D, both in buccal mucosae (D=1.167, P=.019) and in tongue (D=1.196, P=.038), compared with the control population (1.123 for both locations, respectively).
The present study confirms previous literature data on a close relationship between abnormal vascular architecture and atrophic-erosive OLP. Fractal analysis provided a quantitative descriptor of the complexity of the vascular patterns, which increases in the OLP samples. These data may provide new information on the OLP pathogenesis, as well as serve as morphologic quantifiers for monitoring treatment strategies.
本研究旨在评估萎缩糜烂型口腔扁平苔藓（OLP）的局部血管结构。
我们调查了31例OLP患者和32例健康对照者口腔黏膜的毛细血管结构。通过毛细血管显微镜在体内采集毛细血管图像。我们应用分形分析，根据分形维数（D）量化萎缩糜烂型OLP患者口腔黏膜微血管形态计量学变化。
与对照组人群（两个部位均为1.123）相比，萎缩糜烂型OLP病变的口腔血管网络在颊黏膜（D = 1.167，P = 0.019）和舌部（D = 1.196，P = 0.038）的D值均显著更高。
本研究证实了先前文献中关于异常血管结构与萎缩糜烂型OLP之间密切关系的数据。分形分析提供了血管模式复杂性的定量描述，在OLP样本中这种复杂性增加。这些数据可能为OLP发病机制提供新信息，也可作为监测治疗策略的形态学量化指标。
