Di Stasio Dario, Fiori Fausto, Romano Antonio, Palmieri Annalisa, Mosca Laura, Ruiz Roca Juan Antonio, Lopez-Jornet Pia, Lucchese Alberta
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Università Degli Studi Della Campania "Luigi Vanvitelli", 80128 Naples, Italy.
Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
Int J Mol Sci. 2025 Jun 18;26(12):5824. doi: 10.3390/ijms26125824.
Oral lichen planus (OLP) is a chronic inflammatory disorder of the oral mucosa with a recognized risk of malignant transformation. MicroRNAs, particularly miRNA-21 and miRNA-27b, have been implicated in the pathogenesis and progression of various diseases, including OLP. Their altered expression in saliva may provide diagnostic and prognostic insights for this condition. This systematic review examines the expression profiles of miRNA-21 and miRNA-27b in the saliva of OLP patients to assess their potential as biomarkers. The review was conducted in accordance with PRISMA guidelines and was registered in the PROSPERO database. A comprehensive search was conducted in PubMed, Embase, and Scopus using specific keywords. Retrieved titles and abstracts were screened based on predefined eligibility criteria, and relevant studies were analyzed. The initial search identified 71 studies. After screening, 17 abstracts were selected for full-text review. Following evaluation, 11 studies were excluded, resulting in 6 studies being included. Findings indicate a consistent upregulation of miRNA-21 and a downregulation of miRNA-27b in OLP saliva samples. These alterations suggest a potential role in disease pathogenesis and risk assessment. The dysregulation of miRNA-21 and miRNA-27b in OLP underscores their potential as salivary biomarkers for diagnosis and disease monitoring. Moreover, the non-invasive nature of salivary miRNAs offers promising clinical applications, enhancing early detection and personalized management strategies for OLP.
口腔扁平苔藓（OLP）是一种口腔黏膜的慢性炎症性疾病，具有公认的恶变风险。微小RNA，特别是miRNA - 21和miRNA - 27b，已被证实与包括OLP在内的多种疾病的发病机制和进展有关。它们在唾液中的表达改变可能为这种疾病提供诊断和预后方面的见解。本系统评价旨在研究OLP患者唾液中miRNA - 21和miRNA - 27b的表达谱，以评估它们作为生物标志物的潜力。该评价按照PRISMA指南进行，并在PROSPERO数据库中注册。使用特定关键词在PubMed、Embase和Scopus中进行了全面检索。根据预先确定的纳入标准对检索到的标题和摘要进行筛选，并对相关研究进行分析。初步检索识别出71项研究。筛选后，选择17篇摘要进行全文审查。评估后，排除11项研究，最终纳入6项研究。结果表明，OLP唾液样本中miRNA - 21持续上调，miRNA - 27b下调。这些变化表明它们在疾病发病机制和风险评估中可能发挥作用。OLP中miRNA - 21和miRNA - 27b的失调突出了它们作为唾液生物标志物用于诊断和疾病监测的潜力。此外，唾液微小RNA的非侵入性特性提供了有前景的临床应用，可加强OLP的早期检测和个性化管理策略。
