使用药物清除纳米颗粒治疗局部麻醉药引起的心脏毒性
Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles.
作者信息
Morey Timothy E, Varshney Manoj, Flint Jason A, Rajasekaran Surender, Shah Dinesh O, Dennis Donn M
机构信息
Departments of Anesthesiology and Chemical Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida 32610-0254.
出版信息
Nano Lett. 2004;4(4):757-759. doi: 10.1021/nl049880w.
Abstract
Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.
摘要
由于纳米技术能够制造具有大聚集体颗粒表面积与体积比的纳米级结构，它为治疗药物中毒提供了新的机会。基于乳液的纳米颗粒（直径：118.4 nm）从生理盐溶液的水相中提取布比卡因，并比大乳液（432.0 nm）更大程度地减轻了该药物对豚鼠心脏的心脏毒性。此外，纳米颗粒从人血的水相中隔离了布比卡因，值得在中毒动物模型中进一步研究。
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