美沙酮维持治疗6个月后患者性功能、睡眠及体重状况的研究
A Study of the Sexual Function, Sleep, and Weight Status of Patients after 6 Months of Methadone Maintenance Treatment.
作者信息
Parvaresh Noushin, Sabahi Abdol Reza, Mazhari Shahrzad, Gilani Hoda
机构信息
Associate Professor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Assistant Professor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Addict Health. 2015 Winter-Spring;7(1-2):24-9.
BACKGROUND
Methadone is a synthetic opioid and receptor agonist morphine; thus, its consumption has the effects and side effects of opioid. Methadone maintenance treatment (MMT) is used as an alternative treatment for people who are suffering from substance abuse and do not have the ability to withdraw. Despite its benefits, this drug also has side effects. The purpose of this study was to investigate the effects of methadone treatment on sexual function, sleep, and weight after 6 months.
METHODS
The study subjects consisted of 200 patients who had referred to the Methadone Clinic of Shahid Beheshti Training Hospital, Kerman, Iran, during a 6-month period and were treated using MMT. Data collection tools consisted of the demographic questionnaire, Pittsburgh sleep quality index (PSQI), and Arizona sexual experience scale (ASEX). The questionnaires were completed by the participants before and 6 months after the treatment.
FINDINGS
The results of this study showed that methadone consumption has significant effects on sexual dysfunction, sleep disorders, and weight gain.
CONCLUSION
The consideration of the side effects of MMT can result in consumers' commitment to the treatment.
背景
美沙酮是一种合成阿片类药物，是吗啡受体激动剂；因此，服用美沙酮会产生阿片类药物的作用和副作用。美沙酮维持治疗（MMT）被用作对药物滥用且无法戒毒者的替代治疗方法。尽管有其益处，但这种药物也有副作用。本研究的目的是调查6个月后美沙酮治疗对性功能、睡眠和体重的影响。
方法
研究对象包括200名在6个月期间转诊至伊朗克尔曼市沙希德·贝赫什提培训医院美沙酮诊所并接受MMT治疗的患者。数据收集工具包括人口统计学调查问卷、匹兹堡睡眠质量指数（PSQI）和亚利桑那性体验量表（ASEX）。问卷由参与者在治疗前和治疗6个月后填写。
结果
本研究结果表明，服用美沙酮对性功能障碍、睡眠障碍和体重增加有显著影响。
结论
考虑MMT的副作用可使使用者坚持治疗。
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