Kheradmand Ali, Amini Ranjbar Zahra, Zeynali Zahra, Sabahy Abdol Reza, Nakhaee Nouzar
Department of Psychiatry, Behavioral Sciences Research Center, Taleghani Hospital, Research Development Committee, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Research Center for Social Determinants of Health, Institute of Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IR Iran.
Int J High Risk Behav Addict. 2015 Dec 1;4(4):e23550. doi: 10.5812/ijhrba.23550. eCollection 2015 Dec.
Methadone maintenance has remained the main modality of treatment for opioid dependent subjects. Side effects of methadone treatment may be potential obstacles to its continuation. Sleep quality and sexual function are two culture-based concerns, directly related to patients' compliance with methadone maintenance treatment (MMT) program.
This research was conducted to examine the frequency of sleep disparity and sexual dysfunction in patients under MMT referring to MMT clinics of Kerman, Iran.
In this cross-sectional study, 198 adult subjects under MMT for more than 6 months were enrolled. Measurement tool consisted of Pittsburgh sleep quality index (PSQI), Arizona sexual experience scale (ASEX), the 12-item general health questionnaire (GHQ-12), and a demographic questionnaire. The questionnaires were self-completed, except where individuals were illiterate.
Mean ± SD age of the subjects was 41.2 ± 7.9 years and 93.4% of them were male. More than half of them used heroin. Prevalence of poor sleeping and sexual dysfunction in patients under MMT were 67.7% and 18.2%, respectively. There was no association between sleep quality or sexual dysfunction and demographics or methadone dose. However, a significant correlation was observed between mental health and sleep quality (r =0.16, P = 0.033), and sexual function (r = 0.18, P = 0.011).
Sleep quality showed a poorer profile than sexual function. Therefore, more emphasis should be laid on treatment of sleep disparity during follow up of MMT patients comparing to their sexual function. Patients should be reassured that probable sexual dysfunctions should not be regarded as a consequence of MMT.
美沙酮维持治疗一直是阿片类药物依赖者的主要治疗方式。美沙酮治疗的副作用可能是其持续治疗的潜在障碍。睡眠质量和性功能是两个基于文化的关注点，与患者对美沙酮维持治疗（MMT）项目的依从性直接相关。
本研究旨在调查伊朗克尔曼省美沙酮维持治疗诊所中接受MMT治疗患者的睡眠差异和性功能障碍的发生率。
在这项横断面研究中，纳入了198名接受MMT治疗超过6个月的成年患者。测量工具包括匹兹堡睡眠质量指数（PSQI）、亚利桑那性体验量表（ASEX）、12项一般健康问卷（GHQ - 12）和一份人口统计学问卷。问卷由患者自行填写，文盲患者除外。
受试者的平均年龄±标准差为41.2±7.9岁，其中93.4%为男性。超过一半的人曾使用过海洛因。接受MMT治疗的患者中睡眠不佳和性功能障碍的患病率分别为67.7%和18.2%。睡眠质量或性功能障碍与人口统计学特征或美沙酮剂量之间无关联。然而，观察到心理健康与睡眠质量（r = 0.16，P = 0.033）以及性功能（r = 0.18，P = 0.011）之间存在显著相关性。
睡眠质量比性功能表现出更差的状况。因此，与性功能相比，在MMT患者的随访过程中应更加强调对睡眠差异的治疗。应向患者保证，可能出现的性功能障碍不应被视为MMT的后果。
