The EP3 Receptor: Exploring a New Target for Type 2 Diabetes Therapeutics.
作者信息
Neuman Joshua C, Kimple Michelle E
机构信息
Department of Nutritional Sciences, University of Wisconsin-Madison, Wisconsin, USA.
Department of Medicine, University of Wisconsin-Madison, Wisconsin, USA.
出版信息
J Endocrinol Diabetes Obes. 2013 Jul-Sep;1(1).
Abstract
摘要
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Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor.环氧化酶-2 衍生的前列腺素 E₂ 通过 E-前列腺素 3 受体促进损伤诱导的血管内膜增生。
Circ Res. 2013 Jul 5;113(2):104-14. doi: 10.1161/CIRCRESAHA.113.301033. Epub 2013 Apr 17.
2
The economic costs of diabetes: is it time for a new treatment paradigm?糖尿病的经济成本：是时候采用新的治疗模式了吗？
Diabetes Care. 2013 Apr;36(4):775-6. doi: 10.2337/dc13-0270.
3
Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.前列腺素 E2 受体 EP3 在糖尿病胰岛中被诱导产生，并负调控葡萄糖和激素刺激的胰岛素分泌。
Diabetes. 2013 Jun;62(6):1904-12. doi: 10.2337/db12-0769. Epub 2013 Jan 24.
4
Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor response via decreasing arterial contractility.E-前列腺素 3 受体失活通过降低动脉收缩力来减弱血管紧张素 II 的升压反应。
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3024-32. doi: 10.1161/ATVBAHA.112.254052. Epub 2012 Oct 11.
5
Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.GαZ 蛋白缺失通过β细胞质量扩张来防止饮食诱导的葡萄糖不耐受。
J Biol Chem. 2012 Jun 8;287(24):20344-55. doi: 10.1074/jbc.M112.359745. Epub 2012 Mar 28.
6
Comparison of liraglutide versus other incretin-related anti-hyperglycaemic agents.利拉鲁肽与其他肠促胰岛素相关抗高血糖药物的比较。
Diabetes Obes Metab. 2012 Apr;14 Suppl 2:20-32. doi: 10.1111/j.1463-1326.2012.01575.x.
7
Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms.前列腺素 E2 EP3 受体抑制通过抗炎和抗细胞凋亡机制改善中风损伤。
J Neuroimmunol. 2011 Sep 15;238(1-2):34-43. doi: 10.1016/j.jneuroim.2011.06.014. Epub 2011 Jul 30.
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AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.脂肪特异性磷脂酶A2缺失增加脂肪分解，并预防高脂喂养或瘦素缺乏诱导的肥胖。
Nat Med. 2009 Feb;15(2):159-68. doi: 10.1038/nm.1904. Epub 2009 Jan 11.
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Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.小鼠EP3α、β和γ受体变体可降低体内肿瘤细胞的增殖和肿瘤发生。
J Biol Chem. 2008 May 2;283(18):12538-45. doi: 10.1074/jbc.M800105200. Epub 2008 Jan 29.
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Night eating and obesity in the EP3R-deficient mouse.EP3R基因缺陷小鼠的夜间进食与肥胖
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):3009-14. doi: 10.1073/pnas.0611209104. Epub 2007 Feb 16.
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