Fattahi Fatemeh, Ward Peter A
Department of Pathology, University of Michigan Medical School, Ann Arbor, Mich.
Department of Pathology, University of Michigan Medical School, Ann Arbor, Mich.
Transl Res. 2016 Jan;167(1):1-6. doi: 10.1016/j.trsl.2015.08.003. Epub 2015 Aug 14.
Our Introductory Commentary relates to many topics that are linked to inflammatory responses and how these responses are regulated in order to promote healing of damaged tissues and bring about effective clearance of infectious agents. In non-infectious situations, cells and tissues release products (danger associated molecular patterns) that can trigger damaging inflammatory responses. These products must be effectively dealt with in order to avoid serious tissue injury. We provide a perspective about many decades of research into the inflammatory response and describe strategies that have achieved success in restraining inflammatory responses, as well as many approaches that have not been clinically effective. With development of new technologies such as advanced genomic analysis, highly sensitive and sophisticated mass spectrometry and related approaches, as well as the ability to employ mutagenesis induction, we are beginning to define highly sophisticated molecular pathways that previously were opaque. This progress may well have clinical relevance, and we may be on the edge of a scientific revolution in the broad area of inflammation.
我们的引言评论涉及许多与炎症反应相关的主题，以及这些反应如何被调节以促进受损组织的愈合并实现感染因子的有效清除。在非感染情况下，细胞和组织会释放可引发破坏性炎症反应的产物（危险相关分子模式）。必须有效处理这些产物以避免严重的组织损伤。我们提供了关于数十年来炎症反应研究的观点，并描述了在抑制炎症反应方面取得成功的策略，以及许多尚未在临床上有效的方法。随着先进基因组分析、高灵敏度和精密质谱等新技术以及诱变诱导能力的发展，我们开始定义以前不明确的高度复杂的分子途径。这一进展很可能具有临床相关性，并且我们可能正处于炎症广泛领域科学革命的边缘。
