通过CD34表达评估食管和口腔鳞状细胞癌中的微血管情况

Evaluation of Microvascularity by CD34 Expression in Esophagus and Oral Squamous Cell Carcinoma.

作者信息

Shahsavari Fatemeh, Farhadi Sareh, Sadri Donia, Sedehi Marzieh

机构信息

Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran.

Assistant Professor, Department of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, No. 177, Fifth Golestan St, Pasdaran St, Tehran, Iran, Phone: +98 21 22542238, e-mail:

出版信息

J Contemp Dent Pract. 2015 Jun 1;16(6):458-62. doi: 10.5005/jp-journals-10024-1706.

DOI:10.5005/jp-journals-10024-1706

PMID:26323448

Abstract

AIM

The present study was scheduled to evaluate microvascularity by CD34 expression in esophagus and oral squamous cell carcinoma.

MATERIALS AND METHODS

This study was scheduled using 40 paraffin blocked samples including 20 of oral SCC and 20 of esophagus ones and Immunohistochemical staining was conducted using CD34 monoclonal antibody. Exact fisher test was used to evaluate frequency of expression between two studied groups.

RESULTS

There was significant correlation between age and tumor size with CD34 expression in oral SCC samples (p < 0.05) and no significant correlation between sex and tumor differentiation level (grading) (p > 0.05). Also, there was no significant correlation between age, sex, tumor size and tumor differentiation level (grading) with CD34 expression in esophagus SCC samples (p > 0.05). There was no significant difference of CD34 expression frequency in oral and esophagus SCC (p = 0/583). Finally, CD34 expression was reported 'high' for major cases of esophagus and oral SCCs.

CONCLUSION

It seems, other angiogenetic or nonangiogenetic factors except CD34 may play more important role and explain the different clinical behavior of SCC at recent different locations.

CLINICAL SIGNIFICANCE

Other factors would be considered along with CD34 expression to interpret different clinical behavior of SCC at recent different locations.

摘要

目的

本研究旨在通过检测CD34的表达来评估食管癌和口腔鳞状细胞癌的微血管情况。

材料与方法

本研究使用40份石蜡包埋样本，其中包括20份口腔鳞状细胞癌样本和20份食管癌样本，并使用CD34单克隆抗体进行免疫组织化学染色。采用确切概率法评估两组研究对象中CD34表达的频率。

结果

在口腔鳞状细胞癌样本中，年龄和肿瘤大小与CD34表达之间存在显著相关性（p<0.05），而性别与肿瘤分化程度（分级）之间无显著相关性（p>0.05）。此外，在食管鳞状细胞癌样本中，年龄、性别、肿瘤大小和肿瘤分化程度（分级）与CD34表达之间均无显著相关性（p>0.05）。口腔鳞状细胞癌和食管鳞状细胞癌中CD34表达频率无显著差异（p=0.583）。最后，大多数食管和口腔鳞状细胞癌病例中CD34表达为“高”。