Kanakaraj P, Singh M
Indian J Biochem Biophys. 1989 Dec;26(6):381-5.
The cholesterol feeding in rabbits leads to an increase in the levels of cholesterol and phospholipids in plasma and erythrocytes. The increases in cholesterol (C) level is more than that of phospholipids (P) thereby resulting in increase of C/P ratio. The levels of phosphatidylcholine and sphingomyelin are increased in plasma and that of phosphatidylcholine in erythrocytes. Under in vitro conditions the incubation of normal human erythrocytes in cholesterol-enriched plasma (CEP) leads to increase in the cholesterol level, whereas there is no change in phospholipid composition. The deformability of cholesterol-enriched erythrocytes, as measured by their passage time through micropore membranes, under in vivo and in vitro conditions, is significantly decreased.
给兔子喂食胆固醇会导致血浆和红细胞中胆固醇和磷脂水平升高。胆固醇（C）水平的升高幅度大于磷脂（P），从而导致C/P比值增加。血浆中磷脂酰胆碱和鞘磷脂水平升高，红细胞中磷脂酰胆碱水平升高。在体外条件下，正常人红细胞在富含胆固醇的血浆（CEP）中孵育会导致胆固醇水平升高，而磷脂组成没有变化。在体内和体外条件下，通过富含胆固醇的红细胞穿过微孔膜的时间来测量，其变形性显著降低。
