Grover Chander, Khurana Ananta, Bhattacharya Sambit Nath, Sharma Arun
Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi, India.
Indian J Dermatol Venereol Leprol. 2015 Sep-Oct;81(5):472-7. doi: 10.4103/0378-6323.163787.
Partial nail avulsion with lateral chemical matricectomy is the treatment of choice for ingrown toenails. Phenol (88%) is the most widely used chemical agent but prolonged postoperative drainage and collateral damage are common. Sodium hydroxide (NaOH) 10% has fewer side-effects.
Adult, consenting patients with ingrown toenails were alternately allocated into two treatment groups in the order of their joining the study, to receive either 88% phenol (Group 1, n = 26) or 10% NaOH (Group 0, n = 23) chemical matricectomy. The patients as well as the statistician were blinded to the agent being used. Post-procedure follow-up evaluated median duration of pain, discharge, and healing along with recurrence, if any, in both the groups. The group wise data was statistically analyzed.
Both the groups responded well to treatment with the median duration of postoperative pain being 7.92 days in Group 0 and 16.25 days in Group 1 (P < 0.202). Postoperative discharge continued for a median period of 15.42 days (Group 0) and 18.13 days (Group 1) (P < 0.203). The tissue condition normalized in 7.50 days (Group 0) and 15.63 days (Group 1) (P < 0.007).
Limited postsurgical follow up of 6 months is a limitation of the study.
Chemical matricectomy using NaOH is as efficacious as phenolisation, with the advantage of faster tissue normalization.
部分甲床撕脱联合外侧化学甲床切除术是治疗嵌甲的首选方法。88%的苯酚是最广泛使用的化学制剂，但术后引流时间长和附带损伤很常见。10%的氢氧化钠（NaOH）副作用较少。
成年且同意参与的嵌甲患者按加入研究的顺序交替分配到两个治疗组，分别接受88%苯酚（第1组，n = 26）或10% NaOH（第0组，n = 23）化学甲床切除术。患者和统计人员均对所使用的制剂不知情。术后随访评估两组疼痛、引流和愈合的中位持续时间以及是否复发。对分组数据进行统计学分析。
两组对治疗反应良好，第0组术后疼痛中位持续时间为7.92天，第1组为16.25天（P < 0.202）。术后引流中位持续时间分别为15.42天（第0组）和18.13天（第1组）（P < 0.203）。组织状况分别在7.50天（第0组）和15.63天（第1组）恢复正常（P < 0.007）。
6个月有限的术后随访是本研究的一个局限性。
使用NaOH进行化学甲床切除术与苯酚治疗效果相同，具有组织恢复正常更快的优势。
