肝炎：HBx 蛋白对 HBV 的表观遗传控制——打破束缚？
Hepatitis: Epigenetic control of HBV by HBx protein--releasing the break?
机构信息
Institute of Virology, Technische Universität München and the Helmholtz Zentrum München, Trogerstrasse 30, D-81675 München, Germany.
出版信息
Nat Rev Gastroenterol Hepatol. 2015 Oct;12(10):558-9. doi: 10.1038/nrgastro.2015.152. Epub 2015 Sep 1.
PMID:26323877
Abstract
HBV persists by depositing covalently closed circular DNA (cccDNA) into the nucleus of infected host cells. HBV X protein (HBx) is a crucial determinant for regulating HBV activity, but the molecular details have not been fully understood. A new role for HBx in regulating cccDNA transcription has now been identified.
摘要
HBV 通过将共价闭合环状 DNA (cccDNA) 沉积到受感染宿主细胞的核中来持续存在。HBV X 蛋白 (HBx) 是调节 HBV 活性的关键决定因素，但分子细节尚未完全理解。现在已经确定了 HBx 在调节 cccDNA 转录中的新作用。
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